RT Journal Article
T1 Prognosis Parameters of Oral Carcinomas Developed in Proliferative Verrucous Leukoplakia: A Systematic Review and Meta-Analysis
A1 González-Moles, Miguel Ángel
A1 Warnakulasuriya, Saman
A1 Ramos-García, Pablo
K1 Malignant transformation
K1 Meta-analysis
K1 Oral cancer
K1 Prognosis
K1 Proliferative verrucous leukoplakia
K1 Systematic review
K1 Invasividad neoplásica
K1 Metaanálisis
K1 Neoplasias de la boca
K1 Pronóstico
K1 Carcinoma verrugoso
K1 Leucoplasia
K1 Revisión sistemática
AB Proliferative verrucous leukoplakia (PVL) is contemplated by the World Health Organization (WHO) as an oral potentially malignant disorder (OPMD) with a high the highest malignant transformation ratio among all OPMD (approximately 50%). Our aim was to evaluate the current evidence in relation to the prognosis of oral carcinoma developed in patients with proliferative verrucous leukoplakia (PVL-OC). We searched PubMed, Embase, Web of Science and Scopus for published studies (upper date limit = June 2021). We evaluated the quality of studies (QUIPS tool). We carried out meta-analyses, examined inter-study heterogeneity through subgroup and meta-regression analyses, and performed sensitivity and small-study effects analyses to test the stability and reliability of results. 23 studies met inclusion criteria (505 patients with PVL, of which 288 developed a total of 504 carcinomas). The meta-analyzed overall mortality rate was 21.29% (pooled proportions [PP] = 95% confidence intervals [CI] = 8.77-36.36) for PVL-OC, clearly lower than the 34.7-50% mortality rate for conventional oral cancer reported in previous studies. In comparison with a single study reporting on conventional oral cancers, mortality was significantly lower for PVL-OC (hazard ratio = 0.29 [95%CI = 0.10-0.89], p = 0.03). Univariable meta-regression verified that case series that presented higher proportions of verrucous carcinomas showed a better survival of PVL-OC (p = 0.05), but not with higher proportion of oral squamous cell carcinomas (p = 0.74). Significant differences were not found for other relevant variables such as follow up period (p = 0.44) or multiple tumor development (p = 0.74). In conclusion, PVL-OC show favorable prognostic parameters, especially with regard to the mortality rate.
PB MDPI
YR 2021
FD 2021-09-28
LK http://hdl.handle.net/10668/4126
UL http://hdl.handle.net/10668/4126
LA en
NO González-Moles MÁ, Warnakulasuriya S, Ramos-García P. Prognosis Parameters of Oral Carcinomas Developed in Proliferative Verrucous Leukoplakia: A Systematic Review and Meta-Analysis. Cancers. 2021 Sep 28;13(19):4843
DS RISalud
RD Apr 19, 2025