RT Journal Article
T1 Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection.
A1 Lopez-Lopez, Pedro
A1 Rivero-Juarez, Antonio
A1 Frias, Mario
A1 Machuca, Isabel
A1 Caballero-Gomez, Javier
A1 Olivas, Israel
A1 Camacho, Angela
A1 Risalde, Maria de Los Angeles
A1 Garcia-Bocanegra, Ignacio
A1 Rivero, Antonio
K1 HIV
K1 Progins
K1 Hepatitis E virus
K1 Progesterone-receptor
K1 Protect
K1 Susceptibility
K1 Symptoms
AB Mutations in the progesterone receptor (PR) gene, PROGINS, have been studied in relation to hepatitis E virus (HEV) infection. Patients with the PROGINS gene may develop a worse clinical course of hepatitis E. The aim of our study was to evaluate the influence of PROGINS on the susceptibility to and the clinical course of HEV infection in HIV patients. This study included patients with HIV who were evaluated in previous prospective studies for the prevalence and incidence of HEV. The following three groups of patients were studied: (i) never infected, (ii) past infections, and (iii) recently infected. We determined the PR genotype to evaluate the proportion of patients who were homozygous for PROGINS according to HEV infection. We also compared the proportion of PROGINS carriers with a recent HEV infection according to their symptomatology. In this study, 311 patients infected with HIV were included. Of those patients, 198 were homozygous wild type (63.7%), 91 were heterozygous (29.3%), and 22 were homozygous PROGINS (7.1%). We found that the homozygous PROGINS genotype in women was associated with a lower HEV seroprevalence. In addition, in patients with a recent HEV infection, none of those homozygous for PROGINS presented symptoms. The PROGINS mutation plays a protective role against HEV infection and is associated with subclinical infection in HIV-infected patients, particularly women.
PB Frontiers Research Foundation
SN 1664-302X
YR 2019
FD 2019-10-28
LK http://hdl.handle.net/10668/14776
UL http://hdl.handle.net/10668/14776
LA en
NO López-López P, Rivero-Juarez A, Frias M, Machuca I, Caballero-Gómez J, Olivas I, et al. Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection. Front Microbiol. 2019 Nov 7;10:2617
DS RISalud
RD Apr 9, 2025