RT Journal Article
T1 Neuropsychological functioning in methadone maintenance patients with HIV
A1 Vazquez-Justo, Enrique
A1 Vergara-Moragues, Esperanza
A1 Pinon Blanco, Adolfo
A1 Guillen Gestoso, Carlos
A1 Perez-Garcia, Miguel
K1 HIV infection
K1 Neuropsychological performance
K1 Intravenous drug users
K1 Cognitive reserve
K1 Methadone maintenance
K1 Human-immunodeficiency-virus
K1 Positive drug-users
K1 Neurocognitive disorders
K1 Substance use
K1 Cognitive impairment
K1 Edinburgh cohort
K1 Working-memory
K1 Depressed mood
K1 Rna levels
K1 Individuals
AB Although highly active antiretroviral therapy (HAART) has improved survival rates of HIV patients, HIV-associated neurocognitive disorders (HAND) still exist in a highly prevalent group of persons with this disease. In this study we seek to evaluate the influence of drug use in the neuropsychological performance of seropositive drug users. We carried out an extensive neuropsychological evaluation and compared the performance of seropositive drug users (n = 90) with that of a control group of seronegative drug users (n = 48). The results reveal that methadone maintenance programmes can make the seropositive subject neuropsychologically vulnerable. Likewise, we found that giving up drugs have a protective effect in the presence of neuropsychological alterations associated with HIV. These findings lead us to suggest that seropositivity is not sufficient to explain the neuropsychological alterations of seropositive drug users, noting that these alterations are multifactorial. (C) 2016 Fundacion Universitaria Konrad Lorenz. Published by Elsevier Espana, S.L.U.
PB Foundation advancement psychology
SN 0120-0534
YR 2016
FD 2016-09-01
LK http://hdl.handle.net/10668/18880
UL http://hdl.handle.net/10668/18880
LA en
DS RISalud
RD Apr 8, 2025