RT Journal Article
T1 Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study.
A1 Juncal-Ruiz, Maria
A1 Riesco-Davila, Laura
A1 Vazquez-Bourgon, Javier
A1 Ortiz-Garcia de la Foz, Victor
A1 Mayoral-Van Son, Jacqueline
A1 Ayesa-Arriola, Rosa
A1 Setien-Suero, Esther
A1 Leza, Juan Carlos
A1 Lopez-Hoyos, Marcos
A1 Crespo-Facorro, Benedicto
K1 cytokines
K1 neuroinflammation
K1 psychosis
K1 toll-like receptors
AB Toll-like receptors (TLRs) are a pivotal component of the innate immune system that seem to have a role in the pathogenesis of psychosis. The purpose of this work was to compare the expression and functionality of 9 TLRs in three peripheral blood mononuclear cells (PBMCs) (monocytes, B cells, and T cells) between 33 drug-naïve first-episode psychosis (FEP) individuals and 26 healthy volunteers, at baseline and after 3-month of antipsychotic treatment. The expression of TLRs 1-9 were assessed by flow cytometry. For the assessment of the TLR functionality, cells collected in sodium heparin tubes were polyclonally stimulated for 18 h, with different agonists for human TLR1-9. The results of our study highlight the role that TLR5 and TLR8 might play in the pathophysiology of psychosis. We found a lower expression of these receptors in FEP individuals, regarding healthy volunteers at baseline and after 3-month of treatment on the three PBMCs subsets. Most TLRs showed a lower functionality (especially reduced intracellular levels of TNF-α) in patients than in healthy volunteers. These results, together with previous evidence, suggest that individuals with psychosis might show a pattern of TLR expression that differs from that of healthy volunteers, which could vary according to the intensity of immune/inflammatory response.
PB MDPI
YR 2020
FD 2020-08-19
LK http://hdl.handle.net/10668/16165
UL http://hdl.handle.net/10668/16165
LA en
NO Juncal-Ruiz M, Riesco-Davila L, Vazquez-Bourgon J, Ortiz-Garcia de la Foz V, Mayoral-Van Son J, Ayesa-Arriola R, et al. Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study. Int J Mol Sci. 2020 Aug 25;21(17):6106
DS RISalud
RD Apr 6, 2025