%0 Journal Article
%A Juncal-Ruiz, Maria
%A Riesco-Davila, Laura
%A Vazquez-Bourgon, Javier
%A Ortiz-Garcia de la Foz, Victor
%A Mayoral-Van Son, Jacqueline
%A Ayesa-Arriola, Rosa
%A Setien-Suero, Esther
%A Leza, Juan Carlos
%A Lopez-Hoyos, Marcos
%A Crespo-Facorro, Benedicto
%T Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study.
%D 2020
%U http://hdl.handle.net/10668/16165
%X Toll-like receptors (TLRs) are a pivotal component of the innate immune system that seem to have a role in the pathogenesis of psychosis. The purpose of this work was to compare the expression and functionality of 9 TLRs in three peripheral blood mononuclear cells (PBMCs) (monocytes, B cells, and T cells) between 33 drug-naïve first-episode psychosis (FEP) individuals and 26 healthy volunteers, at baseline and after 3-month of antipsychotic treatment. The expression of TLRs 1-9 were assessed by flow cytometry. For the assessment of the TLR functionality, cells collected in sodium heparin tubes were polyclonally stimulated for 18 h, with different agonists for human TLR1-9. The results of our study highlight the role that TLR5 and TLR8 might play in the pathophysiology of psychosis. We found a lower expression of these receptors in FEP individuals, regarding healthy volunteers at baseline and after 3-month of treatment on the three PBMCs subsets. Most TLRs showed a lower functionality (especially reduced intracellular levels of TNF-α) in patients than in healthy volunteers. These results, together with previous evidence, suggest that individuals with psychosis might show a pattern of TLR expression that differs from that of healthy volunteers, which could vary according to the intensity of immune/inflammatory response.
%K cytokines
%K neuroinflammation
%K psychosis
%K toll-like receptors
%~