TY  - JOUR
AU  - Peyvandi, Flora
AU  - Mannucci, Pier M
AU  - Garagiola, Isabella
AU  - El-Beshlawy, Amal
AU  - Elalfy, Mohsen
AU  - Ramanan, Vijay
AU  - Eshghi, Peyman
AU  - Hanagavadi, Suresh
AU  - Varadarajan, Ramabadran
AU  - Karimi, Mehran
AU  - Manglani, Mamta V
AU  - Ross, Cecil
AU  - Young, Guy
AU  - Seth, Tulika
AU  - Apte, Shashikant
AU  - Nayak, Dinesh M
AU  - Santagostino, Elena
AU  - Mancuso, Maria Elisa
AU  - Sandoval Gonzalez, Adriana C
AU  - Mahlangu, Johnny N
AU  - Bonanad Boix, Santiago
AU  - Cerqueira, Monica
AU  - Ewing, Nadia P
AU  - Male, Christoph
AU  - Owaidah, Tarek
AU  - Soto Arellano, Veronica
AU  - Kobrinsky, Nathan L
AU  - Majumdar, Suvankar
AU  - Perez Garrido, Rosario
AU  - Sachdeva, Anupam
AU  - Simpson, Mindy
AU  - Thomas, Mathew
AU  - Zanon, Ezio
AU  - Antmen, Bulent
AU  - Kavakli, Kaan
AU  - Manco-Johnson, Marilyn J
AU  - Martinez, Monica
AU  - Marzouka, Esperanza
AU  - Mazzucconi, Maria G
AU  - Neme, Daniela
AU  - Palomo Bravo, Angeles
AU  - Paredes Aguilera, Rogelio
AU  - Prezotti, Alessandra
AU  - Schmitt, Klaus
AU  - Wicklund, Brian M
AU  - Zulfikar, Bulent
AU  - Rosendaal, Frits R
PY  - 2016
DO  - 10.1056/NEJMoa1516437
SN  - 0028-4793
UR  - http://hdl.handle.net/10668/2671
T2  - The New England Journal of Medicine
AB  - BACKGROUNDThe development of neutralizing anti-factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy.METHODSWe conducted a randomized trial to assess the incidence of...
LA  - en
PB  - Massachusetts Medical Society
KW  - Adulto
KW  - Anciano
KW  - Anticuerpos neutralizantes
KW  - Niño
KW  - Adolescente
KW  - Niño preescolar
KW  - Relación dosis-respuesta de medicamentos
KW  - Farmacoterapia combinada
KW  - Factor VIII
KW  - Hemofilia A
KW  - Hemorragia
KW  - Humanos
KW  - Incidencia
KW  - Lactante
KW  - Inyecciones subcutáneas
KW  - Isoanticuerpos
KW  - Masculino
KW  - Mediana edad
KW  - Modelos de riesgos proporcionales
KW  - Adulto joven
KW  - Factor de von Willebrand
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Antibodies::Antibodies, Neutralizing
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Child
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Child::Child, Preschool
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Dose-Response Relationship, Drug
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Therapy, Combination
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Blood Coagulation Factors::Factor VIII
KW  - Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Hemorrhagic Disorders::Hemophilia A
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Infant
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Injections::Injections, Subcutaneous
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Antibodies::Isoantibodies
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young Adult
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Blood Coagulation Factors::von Willebrand Factor
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adolescent
TI  - A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A.
TY  - research article
ER  -