RT Journal Article
T1 Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre
A1 Castejón-Vega, Beatriz
A1 Battino, Maurizio
A1 Quiles, José L.
A1 Bullon, Beatriz
A1 Cordero, Mario D.
A1 Bullón, Pedro
K1 Papillon–Lefèvre syndrome
K1 Mitochondria
K1 Coenzyme Q10
K1 Enfermedad de Papillon-Lefevre
K1 Mitocondrias
K1 Ubiquinona
AB The Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder caused by mutations in the Cathepsin C (CTSC) gene, characterized by periodontitis and palmoplantar hyperkeratosis. The main inflammatory deficiencies include oxidative stress and autophagic dysfunction. Mitochondria are the main source of reactive oxygen species; their impaired function is related to skin diseases and periodontitis. The mitochondrial function has been evaluated in PLS and mitochondria have been targeted as a possible treatment for PLS. We show for the first time an important mitochondrial dysfunction associated with increased oxidative damage of mtDNA, reduced CoQ10 and mitochondrial mass and aberrant morphologies of the mitochondria in PLS patients. Mitochondrial dysfunction, determined by oxygen consumption rate (OCR) in PLS fibroblasts, was treated with CoQ10 supplementation, which determined an improvement in OCR and a remission of skin damage in a patient receiving a topical administration of a cream enriched with CoQ10 0.1%. We provide the first evidence of the role of mitochondrial dysfunction and CoQ10 deficiency in the pathophysiology of PLS and a future therapeutic option for PLS.
PB MDPI
YR 2021
FD 2021-01-12
LK http://hdl.handle.net/10668/4019
UL http://hdl.handle.net/10668/4019
LA en
NO Castejón-Vega B, Battino M, Quiles JL, Bullon B, Cordero MD, Bullón P. Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre. Antioxidants (Basel). 2021 Jan 12;10(1):95
DS RISalud
RD Apr 19, 2025