RT Generic
T1 Predictors of clinical evolution of SARS-CoV-2 infection in hematological patients: A systematic review and meta-analysis.
A1 Carrara, Elena
A1 Razzaboni, Elisa
A1 Azzini, Anna Maria
A1 De-Rui, Maria Elena
A1 Pinho-Guedes, Mariana Nunes
A1 Gorska, Anna
A1 Giannella, Maddalena
A1 Bussini, Linda
A1 Bartoletti, Michele
A1 Arbizzani, Federica
A1 Palacios-Baena, Zaira R
A1 Caponcello, Giulia
A1 Maldonado, Natalia
A1 Rodriguez-Baño, Jesus
A1 Visco, Carlo
A1 Krampera, Mauro
A1 Tacconelli, Evelina
K1 COVID-19
K1 determinants
K1 hematological malignancies
K1 mortality
K1 severity
AB Main aim of this systematic review is to quantify the risk and identify predictors of clinical evolution of SARS-CoV-2 in hematological patients compared to different control populations. Two independent reviewers screened the literature assessing clinical outcomes of SARS-CoV-2 infection in adult patients with active hematological malignancies published up to June 2021. Primary outcome was COVID-19 related mortality, secondary outcomes were hospital and intensive-care admission, mechanical ventilation (MV), and thromboembolic events. Variables related to study setting, baseline patients' demographic, comorbidities, underlying hematological disease, ongoing chemotherapy, COVID-19 presentation, and treatments were extracted. A total of 67 studies including 10,061 hematological patients and 111,143 controls were included. Most of the studies were retrospective cohorts (51 studies, 76%) and only 19 (13%) provided data for a control group. A significant increased risk of clinical progression in the hematological population compared to the controls was found in terms of COVID-19 related mortality (OR, 2.12; 95% CI, 1.77-2.54), hospitalization (OR, 1.98; 95% CI, 1.15-3.43), intensive-care admission (OR, 1.77; 95% CI, 1.38-2.26), and MV (OR, 2.17; 95% CI, 1.71-2.75). The risk remained significantly higher in the subgroup analysis comparing hematological patients versus solid cancer. Meta-regression analysis of uncontrolled studies showed that older age, male sex, and hypertension were significantly related to worse clinical outcomes of COVID-19 in hematological population. Older age and hypertension were found to be associated also to thromboembolic events. In conclusion, hematological patients have a higher risk of COVID-19 clinical progression compared to both the general population and to patients with solid cancer.
PB Wiley-Blackwell Publishing Ltd.
YR 2022
FD 2022-10-20
LK http://hdl.handle.net/10668/22039
UL http://hdl.handle.net/10668/22039
LA en
NO Carrara E, Razzaboni E, Azzini AM, De Rui ME, Pinho Guedes MN, Gorska A, et al. Predictors of clinical evolution of SARS-CoV-2 infection in hematological patients: A systematic review and meta-analysis. Hematol Oncol. 2023 Feb;41(1):16-25.
DS RISalud
RD Aug 21, 2025