RT Journal Article
T1 Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
A1 Mena-Vazquez, Natalia
A1 Rojas-Gimenez, Marta
A1 Jimenez Nuñez, Francisco Gabriel
A1 Manrique-Arija, Sara
A1 Rioja, José
A1 Ruiz-Limón, Patricia
A1 Ureña, Inmaculada
A1 Castro-Cabezas, Manuel
A1 Valdivielso, Pedro
A1 Fernández-Nebro, Antonio
K1 Rheumatoid arthritis
K1 Postprandial lipemia
K1 Apolipoprotein B48
K1 Subclinical atherosclerosis
K1 Cross-sectional studies
K1 Artritis reumatoide
K1 Apolipoproteína B-48
K1 Aterosclerosis
K1 Estudios transversales
K1 Andalucía
AB Objective: To describe postprandial lipemia in patients with rheumatoid arthritis (RA) and to analyze its association with subclinical atherosclerosis measured as carotid intima-media thickness (cIMT). Methods: We performed an observational study of 40 patients with RA and 40 sex and age-matched controls. Patients with dyslipidemia were excluded. Pathologically increased cIMT was defined as a carotid thickness greater than the 90th percentile (>p90) for age and sex. Fasting and postprandial plasma lipids, cholesterol, triglycerides, apolipoprotein B48 (ApoB48), and total ApoB were evaluated. The other variables included were clinical and laboratory values, Framingham score, and the 28-joint Disease Activity Score (DAS28). Two multivariate models were constructed to identify factors associated with pathologic cIMT in patients with RA. Results: Fasting lipid values were similar in patients with RA and controls, although those of postprandial ApoB48 were higher (median (IQR), 14.4 (10.8–12.1) vs. 12.1 (2.3–9,8); p = 0.042). Pathologic cIMT was recorded in 10 patients with RA (25%) and nine controls (22.5%). In patients with RA, pathologic cIMT was associated with postprandial ApoB48 (OR (95% CI), 1.15 (1.0–1.3)) and total ApoB (OR [95% CI], 1.12 [1.1–1.2]). The second model revealed a mean increase of 0.256 mm for cIMT in patients with elevated anticitrullinated protein antibodies (ACPAs). Conclusion: Postprandial ApoB48 levels in patients with RA are higher than in controls. Postprandial ApoB48 and total ApoB levels and markers of severity, such as ACPAs, are associated with pathologic cIMT in patients with RA. Our findings could indicate that these atherogenic particles have a negative effect on the endothelium.
PB MDPI
YR 2020
FD 2020-08-02
LK http://hdl.handle.net/10668/4081
UL http://hdl.handle.net/10668/4081
LA en
NO Mena-Vázquez N, Rojas-Gimenez M, Jimenez Nuñez FG, Manrique-Arija S, Rioja J, Ruiz-Limón P, et al. Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis. J Clin Med. 2020 Aug 2;9(8):2483
DS RISalud
RD Apr 8, 2025