RT Journal Article
T1 Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity
A1 Cuevas, Belen
A1 Arroba, Ana I.
A1 de los Reyes, Carolina
A1 Gomez-Jaramillo, Laura
A1 Gonzalez-Montelongo, M. Carmen
A1 Zubia, Eva
K1 diterpenoids
K1 brown algae
K1 Rugulopteryx okamurae
K1 anti-inflammatory
K1 nitric oxide
K1 cytokine
K1 microglia
K1 macrophages
K1 invasive algae
AB Brown algae of the Family Dictyotaceae produce an array of structurally diverse terpenoids, whose biomedical potential in the anti-inflammatory area has been scarcely explored. Herein, the chemical study of the alga Rugulopteryx okamurae has led to the isolation of ten new diterpenoids: rugukadiol A (1), rugukamurals A-C (2-4), and ruguloptones A-F (6-10). The structures of the new compounds were established by spectroscopic means. Compound 1 exhibits an unprecedented diterpenoid skeleton featuring a bridged tricyclic undecane system. Compounds 2-10 belong to the secospatane class of diterpenoids and differ by the oxygenated functions that they contain. In anti-inflammatory assays, the new diterpenoid 1 and the secospatanes 5 and 10 significantly inhibited the production of the inflammatory mediator NO in LPS-stimulated microglial cells Bv.2 and macrophage cells RAW 264.7. Moreover, compounds 1 and 5 were found to strongly inhibit the expression of Nos2 and the pro-inflammatory cytokine Il1b in both immune cell lines.
PB Mdpi
SN 1660-3397
YR 2021
FD 2021-11-27
LK https://hdl.handle.net/10668/25243
UL https://hdl.handle.net/10668/25243
LA en
NO Cuevas B, Arroba AI, de Los Reyes C, Gómez-Jaramillo L, González-Montelongo MC, Zubía E. Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity. Mar Drugs. 2021;19(12):677. Published 2021 Nov 27.
NO This research was funded by Junta de Andalucía, Spain (ITI-FEDER, research project ITI-0012-2019).
DS RISalud
RD Aug 18, 2025