RT Journal Article
T1 Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity
A1 Cuevas, Belen
A1 Arroba, Ana I.
A1 de los Reyes, Carolina
A1 Gomez-Jaramillo, Laura
A1 Gonzalez-Montelongo, M. Carmen
A1 Zubia, Eva
K1 diterpenoids
K1 brown algae
K1 Rugulopteryx okamurae
K1 anti-inflammatory
K1 nitric oxide
K1 cytokine
K1 microglia
K1 macrophages
K1 invasive algae
K1 Feeding-deterrent activity
K1 Dictyota-menstrualis
K1 Chinese collection
K1 Nitric-oxide
K1 Marine alga
K1 Seaweed
K1 Secospatane
K1 Cancer
AB Brown algae of the Family Dictyotaceae produce an array of structurally diverse terpenoids, whose biomedical potential in the anti-inflammatory area has been scarcely explored. Herein, the chemical study of the alga Rugulopteryx okamurae has led to the isolation of ten new diterpenoids: rugukadiol A (1), rugukamurals A-C (2-4), and ruguloptones A-F (6-10). The structures of the new compounds were established by spectroscopic means. Compound 1 exhibits an unprecedented diterpenoid skeleton featuring a bridged tricyclic undecane system. Compounds 2-10 belong to the secospatane class of diterpenoids and differ by the oxygenated functions that they contain. In anti-inflammatory assays, the new diterpenoid 1 and the secospatanes 5 and 10 significantly inhibited the production of the inflammatory mediator NO in LPS-stimulated microglial cells Bv.2 and macrophage cells RAW 264.7. Moreover, compounds 1 and 5 were found to strongly inhibit the expression of Nos2 and the pro-inflammatory cytokine Il1b in both immune cell lines.
PB Mdpi
YR 2021
FD 2021-12-01
LK https://hdl.handle.net/10668/25243
UL https://hdl.handle.net/10668/25243
LA en
DS RISalud
RD Apr 17, 2025