RT Journal Article
T1 Prognostic significance of age in 5631 patients with Wilms tumour prospectively registered in International Society of Paediatric Oncology (SIOP) 93-01 and 2001.
A1 Hol, J A
A1 Lopez-Yurda, M I
A1 Van Tinteren, H
A1 Van Grotel, M
A1 Godzinski, J
A1 Vujanic, G
A1 Oldenburger, F
A1 De Camargo, B
A1 Ramírez-Villar, G L
A1 Bergeron, C
A1 Pritchard-Jones, K
A1 Graf, N
A1 Van den Heuvel-Eibrink, M M
AB To enhance risk stratification for Wilms tumour (WT) in a pre-operative chemotherapy setting, we explored the prognostic significance and optimal age cutoffs in patients treated according to International Society of Paediatric Oncology Renal Tumour Study Group (SIOP-RTSG) protocols. Patients(6 months-18 years) with unilateral WT were selected from prospective SIOP 93-01 and 2001 studies(1993-2016). Martingale residual analysis was used to explore optimal age cutoffs. Outcome according to age was analyzed by uni- and multivariable analysis, adjusted for sex, biopsy(yes/no), stage, histology and tumour volume at surgery. 5631 patients were included; median age was 3.4 years(IQR: 2-5.1). Estimated 5-year event-free survival (EFS) and overall survival (OS) were 85%(95%CI 83.5-85.5) and 93%(95%CI 92.0-93.4). Martingale residual plots detected no optimal age cutoffs. Multivariable analysis showed lower EFS with increasing age(linear trend P Although optimal age cutoffs could not be identified, we demonstrated the prognostic significance of age as well as previously described cutoffs for EFS (2 and 4 years) and OS (4 years) in children with WT treated with pre-operative chemotherapy. These findings encourage the consideration of age in the design of future SIOP-RTSG protocols.
YR 2019
FD 2019-08-19
LK http://hdl.handle.net/10668/14409
UL http://hdl.handle.net/10668/14409
LA en
DS RISalud
RD Apr 17, 2025