RT Journal Article
T1 Pros and Cons of Clinical Basophil Testing (BAT).
A1 Hoffmann, Hans Jürgen
A1 Knol, Edward F
A1 Ferrer, Martha
A1 Mayorga, Lina
A1 Sabato, Vito
A1 Santos, Alexandra F
A1 Eberlein, Bernadette
A1 Nopp, Anna
A1 MacGlashan, Donald
K1 Allergy
K1 BAT
K1 Basophil granulocyte
K1 CD63
K1 Chronic urticaria
K1 Mast cell
AB We review basophil testing by flow cytometry with an emphasis on advantages and disadvantages. There are many tools available to assess the presence and severity of allergic diseases in patients. For 50 years, peripheral blood basophils have been used as tools to study these diseases. It is a very accessible cell that binds IgE antibody and secretes the classical mediators responsible for the symptoms of allergic reactions. In the last decade, an even more accessible methodology, using flow cytometry, has been developed to enhance the ability to use basophils for both mechanistic and clinical diagnostics. Basophil testing has been included in diagnostics for different forms of allergies as well as to monitor disease status. A variety of studies have begun to establish both precise methods and their clinical relevance for disease diagnosis, but there remain some important questions on how to take optimal advantage of the behaviours of basophils.
PB Springer
YR 2016
FD 2016-07-13
LK http://hdl.handle.net/10668/10266
UL http://hdl.handle.net/10668/10266
LA en
NO Hoffmann HJ, Knol EF, Ferrer M, Mayorga L, Sabato V, Santos AF, et al. Pros and Cons of Clinical Basophil Testing (BAT). Curr Allergy Asthma Rep. 2016 Jul;16(8):56
DS RISalud
RD Apr 5, 2025