RT Journal Article
T1 Prognostic Impact of Hyponatremia and Hypernatremia in COVID-19 Pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) Registry Analysis.
A1 Ruiz-Sánchez, Jorge Gabriel
A1 Núñez-Gil, Ivan J
A1 Cuesta, Martin
A1 Rubio, Miguel A
A1 Maroun-Eid, Charbel
A1 Arroyo-Espliguero, Ramón
A1 Romero, Rodolfo
A1 Becerra-Muñoz, Victor Manuel
A1 Uribarri, Aitor
A1 Feltes, Gisela
A1 Trabattoni, Daniela
A1 Molina, María
A1 García Aguado, Marcos
A1 Pepe, Martino
A1 Cerrato, Enrico
A1 Alfonso, Emilio
A1 Castro Mejía, Alex Fernando
A1 Roubin, Sergio Raposeiras
A1 Buzón, Luis
A1 Bondia, Elvira
A1 Marin, Francisco
A1 López Pais, Javier
A1 Abumayyaleh, Mohammad
A1 D'Ascenzo, Fabrizio
A1 Rondano, Elisa
A1 Huang, Jia
A1 Fernandez-Perez, Cristina
A1 Macaya, Carlos
A1 de Miguel Novoa, Paz
A1 Calle-Pascual, Alfonso L
A1 Estrada Perez, Vicente
A1 Runkle, Isabelle
A1 HOPE COVID-19 investigators, 
K1 COVID-19
K1 SARS-COV2
K1 hypernatremia
K1 hyponatremia
K1 mortality
K1 sepsis
AB Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sepsis, or intensive therapy (IT) in patients hospitalized with SARS-COV2 pneumonia. This is a retrospective study of the HOPE-COVID-19 registry, with data collected from January 1th through April 31th, 2020. We selected all hospitalized adult patients with RT-PCR-confirmed SARS-COV2 pneumonia and a registered admission serum sodium level (SNa). Patients were classified as hyponatremic (SNa 145 mmol/L). Multivariable analyses were performed to elucidate independent relationships of admission hyponatremia and hypernatremia, with mortality, sepsis, or IT during hospitalization. Four thousand six hundred sixty-four patients were analyzed, median age 66 (52-77), 58% males. Death occurred in 988 (21.2%) patients, sepsis was diagnosed in 551 (12%) and IT in 838 (18.4%). Hyponatremia was present in 957/4,664 (20.5%) patients, and hypernatremia in 174/4,664 (3.7%). Both hyponatremia and hypernatremia were associated with mortality and sepsis. Only hyponatremia was associated with IT. In conclusion, hyponatremia and hypernatremia at admission are factors independently associated with mortality and sepsis in patients hospitalized with SARS-COV2 pneumonia. https://clinicaltrials.gov/ct2/show/NCT04334291, NCT04334291.
SN 1664-2392
YR 2020
FD 2020-11-30
LK https://hdl.handle.net/10668/27053
UL https://hdl.handle.net/10668/27053
LA en
DS RISalud
RD Aug 8, 2025