RT Journal Article
T1 Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects.
A1 Coin-Aragüez, Leticia
A1 Pavon, Francisco Javier
A1 Contreras, Alba
A1 Gentile, Adriana-Mariel
A1 Lhamyani, Said
A1 De Diego-Otero, Yolanda
A1 Casado, Yolanda
A1 Oliva Olivera, Wilfredo
A1 Olveira, Gabriel
A1 Tinahones, Francisco J
A1 Perez Costillas, Lucia
A1 El Bekay, Rajaa
K1 Adipokines
K1 Adipose tissue
K1 Gene expression profiling
K1 Obesity
AB Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link adipose tissue inflammation to these mental disorders. The analysis of adipokines and inflammation-related markers in adipose tissue could help to elucidate the potential association between obesity and mental health. An observational study was conducted in samples of patients consisting of non-obese and obese subjects, who were diagnosed with anxiety or mood disorders. Gene expression of adiponectin (ADIPOQ), leptin (LEP) and inflammatory markers (IL6, IL1B, TNF, CCL2, CSF3, ITGAM, and PLAUR) were determined in visceral (VAT) and subcutaneous (SAT) adipose tissues. Our results showed that the gene expression of adipokines and inflammation-related markers was higher in the VAT and SAT of obese subjects compared with non-obese subjects. Regarding mental disorders, all the inflammatory genes in the VAT were significantly higher in non-obese subjects with anxiety or mood disorders than in subjects without mental disorders, except for TNF and ITGAM. Additionally, IL6 expression was significantly lower in SAT. In contrast, obese patients diagnosed with anxiety or mood disorders only showed significantly lower expression levels of IL1B in VAT and ADIPOQ in SAT when compared with obese subjects without mental disorders. These data suggest the potential involvement of VAT inflammation in anxiety and mood disorders, involving complex mechanisms which are strongly affected by obesity.
PB Springer Nature
YR 2018
FD 2018-11-06
LK http://hdl.handle.net/10668/13269
UL http://hdl.handle.net/10668/13269
LA en
NO Coín-Aragüez L, Pavón FJ, Contreras A, Gentile AM, Lhamyani S, De Diego-Otero Y, et al. Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects. Sci Rep. 2018 Nov 30;8(1):17518
NO Te authors wish to thank all the subjects for their collaboration. Te CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is part of the ‘Instituto de Salud del Carlos III’ (ISCIII) Project. Authors thank D.W.E. Ramsden for help with the English language version of the text. Tis work was supported in part by grants from the Instituto de Salud Carlos III (ISCIII)/FEDER-UE (PI10/01947, PI13/02628). CTS-7895 and CTS-546 funded by the Regional Ministry of Innovation of the Andalusian Government, Andalusia, Spain; and co-funded by the Fondo Europeo de Desarrollo Regional–FEDER. RE and YDDO are under a contract of a ‘Nicolas Monarde’ (C-0030-2016, RC0006-2015) programme from the Servicio Andaluz de Salud, Regional Ministry of health of the Andalusian Government, Andalusia, Spain. FJP holds a ‘Miguel Servet I’ research contract from ISCIII and ERDF-UE (CP14/00212).
DS RISalud
RD Apr 6, 2025