RT Journal Article
T1 Bile acid malabsorption in patients with chronic diarrhea and Crohn's disease.
A1 Mena Bares, Luisa M
A1 Benitez Cantero, Jose M
A1 Iglesias Flores, Eva
A1 Gros Alcalde, Beatriz
A1 Moreno Ortega, Estefania
A1 Maza Muret, Francisco R
A1 Carmona Asenjo, Elvira
A1 Garcia Sanchez, M  Valle
A1 Vallejo Casas, Juan A
K1 Chronic diarrhea
K1 Crohn’s disease
K1 Bile acid malabsorption
K1 Ileal resection
K1 Bile acid sequestrants
AB Crohn's disease (CD) is a form of inflammatory bowel disease and is mainly characterized by diarrhea and abdominal pain. The aim of our study was to analyze the usefulness of performing a 75SeHCAT scan in CD patients with chronic diarrhea and suspected bile acid malabsorption (BAM). In addition, we aimed to determine whether there was a relationship with the clinical features of the disease and a previous bowel resection. this was an observational cross-sectional study of 39 patients with a diagnosis of CD and chronic diarrhea. All cases underwent a 75SeHCAT scan for BAM diagnosis, after discarding disease activity. the study cohort included 19 females and 20 males. The median age was 44 years and the majority of patients were A2 L1 B1 according to the Montreal classification; 84.6% of patients had undergone a previous bowel resection. BAM was present in 97.4% of patients (100% and 83.3% of patients with and without previous surgery, respectively), which was severe in 92.1% of cases. Treatment with bile acid sequestrants was initiated and a favorable response was obtained in 72.2% of patients. The relationship between BAM degree (moderate or severe), bowel surgery and the response to bile acid sequestrant treatment was also analyzed but not statistically significant. BAM is a frequent cause of diarrhea in CD patients in endoscopic or radiological remission. This condition was present in all patients with a history of a bowel resection. A response to bile acid sequestrants treatment was observed in 73% of patients.
PB Sociedad Espanola de Patologia Digestiva
SN 1130-0108
YR 2018
FD 2018-07-10
LK http://hdl.handle.net/10668/13024
UL http://hdl.handle.net/10668/13024
LA en
NO Mena Bares LMª, Benítez Cantero JM, Iglesias Flores E, Gros Alcalde B, Moreno Ortega E, Maza Muret FR, et al. Bile acid malabsorption in patients with chronic diarrhea and Crohn's disease. Rev Esp Enferm Dig. 2019 Jan;111(1):40-45
DS RISalud
RD Apr 9, 2025