RT Journal Article
T1 Changes in Oxidative Stress and Inflammatory Biomarkers in Fragile Adults over Fifty Years of Age and in Elderly People Exclusively Fed Enteral Nutrition
A1 Mesa, Maria D.
A1 Olza, Josune
A1 Gonzalez-Anton, Carolina
A1 Aguilera, Concepcion M.
A1 Moreno-Torres, Rosario
A1 Jimenez, Africa
A1 Perez de la Cruz, Antonio
A1 Ruperez, Azahara I.
A1 Gil, Angel
K1 Polyunsaturated fatty-acids
K1 Fish-oil
K1 Antiinflammatory properties
K1 Endothelial function
K1 Adhesion molecules
K1 Vitamin-e
K1 Omega-3-fatty-acids
K1 Supplementation
K1 Risk
K1 Association
AB We aim to evaluate whether exclusive feeding of an enteral formula enriched with n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA) affects oxidative stress and the antioxidant defence system and may improve the levels of some relevant inflammatory, and cardiovascular biomarkers in frail adults over fifty years of age and in elderly subjects. Fifty-five patients were divided into two groups and were exclusively fed a newly designed normoproteic and isocaloric enteral formula enriched with eicosapentaenoic (98mg/ d) and docosahexaenoic acids (46mg/ d) (n = 26) or a reference enteral diet (n = 29). Oxidative, inflammatory and cardiovascular risk biomarkers and red blood cell fatty acid profiles were determined at the beginning and after 90 and 180 days of feeding. The n-3 LC-PUFA percentage tended to be higher (p = 0.053) in the experimental group than in the reference group. Administration of the n-3 LC-PUFA diet did not increase oxidative stress or modify plasma antioxidant capacity but decreased antioxidant enzymatic activities. MMP-9 plasma concentration decreased with both formulae, whereas tPAI-1 tended to decrease (p = 0.116) with the administration of the experimental formula. In conclusion, administration of the new n-3 LC-PUFA-enriched product for 6 months did not negatively alter the oxidative status and improved some cardiovascular risk biomarkers.
PB Hindawi ltd
SN 1942-0900
YR 2016
FD 2016-01-01
LK http://hdl.handle.net/10668/19048
UL http://hdl.handle.net/10668/19048
LA en
DS RISalud
RD Apr 11, 2025