TY  - JOUR
AU  - Lee, Ji-Hyeon
AU  - Mellado-Gil, Jose Manuel
AU  - Bahn, Young Jae
AU  - Pathy, Sushrut M.
AU  - Zhang, Ying E.
AU  - Rane, Sushil G.
PY  - 2020
DO  - 10.1038/s41419-020-2365-8
UR  - http://hdl.handle.net/10668/3869
T2  - Cell Death & Disease
AB  - Prevailing insulin resistance and the resultant hyperglycemia elicits a compensatory response from pancreatic islet beta cells (β-cells) that involves increases in β-cell function and β-cell mass. However, the sustained metabolic stress eventually...
LA  - en
PB  - Springer Nature
KW  - Apoptosis
KW  - β-cell
KW  - Glucose
KW  - Glucose intolerance
KW  - Pancreas
KW  - Role
KW  - Diabetes
KW  - Células secretoras de insulina
KW  - Glucosa
KW  - Intolerancia a la glucosa
KW  - Rol
KW  - Factor de crecimiento transformador beta
KW  - Proteína smad3
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Smad Proteins::Smad Proteins, Receptor-Regulated::Smad3 Protein
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intercellular Signaling Peptides and Proteins::Transforming Growth Factors::Transforming Growth Factor beta::Transforming Growth Factor beta1
TI  - Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling
TY  - research article
ER  -