RT Journal Article T1 Gender Differences in Outcomes Following a Pain-Free, Home-Based Exercise Program for Claudication. A1 Manfredini, Roberto A1 Lamberti, Nicola A1 Manfredini, Fabio A1 Straudi, Sofia A1 Fabbian, Fabio A1 Rodriguez Borrego, Maria Aurora A1 Basaglia, Nino A1 Carmona Torres, Juan Manuel A1 Lopez Soto, Pablo Jesus K1 exercise therapy K1 gender K1 peripheral artery disease K1 rehabilitation K1 women AB Background: Peripheral artery disease (PAD) is a common cardiovascular pathology that affects mobility. In previous research, supervised exercise, a recommended treatment for claudication, was less effective in women. This study retrospectively investigated whether functional outcomes exhibit sex differences following a pain-free, home-based exercise program for PAD patients. Materials and Methods: Patients with PAD and claudication enrolled to a structured home-based program from 2003 to 2016 were studied. The program was prescribed at the hospital and based on two daily 10-minute pain-free walking sessions at progressively increasing speed. Outcome measures, which were assessed at baseline and discharge, were pain threshold speed (PTS) and maximal (Smax) during a treadmill test and pain-free walking distance (PFWD) and total distance walked in 6 minutes (6MWD). The ankle-brachial index (ABI), program duration, and patient adherence were determined. Results: A total of 1007 patients (women; nā€‰=ā€‰264; 26%) were enrolled. At baseline, compared to men, women exhibited similar ABI values but lower PTS and PFWD values (pā€‰ PB Mary Ann Liebert, Inc. Publishers YR 2018 FD 2018-09-15 LK http://hdl.handle.net/10668/12954 UL http://hdl.handle.net/10668/12954 LA en NO Manfredini R, Lamberti N, Manfredini F, Straudi S, Fabbian F, Rodriguez Borrego MA, et al. Differences in Outcomes Following a Pain-Free, Home-Based Exercise Program for Claudication. J Womens Health (Larchmt). 2019 Sep;28(9):1313-1321. DS RISalud RD Apr 5, 2025