RT Journal Article
T1 Analysis of Bone Impairment by 3D DXA Hip Measures in Patients With Primary Hyperparathyroidism: A Pilot Study.
A1 Gracia-Marco, Luis
A1 Garcia-Fontana, Beatriz
A1 Ubago-Guisado, Esther
A1 Vlachopoulos, Dimitris
A1 Garcia-Martin, Antonia
A1 Muñoz-Torres, Manuel
K1 3D-DXA
K1 Bone QCT
K1 DXA
K1 Osteoporosis
K1 parathyroid-related disorders
AB Primary hyperparathyroidism (PHPT) has been related to bone loss. Dual-energy x-ray absorptiometry (DXA) cannot distinguish between trabecular and cortical bone compartments but the recently developed three-dimensional (3D)-DXA software might overcome this issue. To examine the differences in DXA-derived areal bone mineral density (aBMD) and 3D-DXA parameters at the hip site between patients with PHPT and a healthy control group. Cross-sectional pilot study. Hospital. 80 adults (59.5 ± 9.1 yrs), 40 with PHPT and 40 age- and sex-matched healthy controls. aBMD (g/cm2) of the femoral neck, trochanter, shaft, and total hip was assessed using DXA. Cortical surface (sBMD, mg/cm2), cortical volumetric BMD (vBMD, mg/cm3), trabecular vBMD (mg/cm3), integral vBMD (mg/cm3) and cortical thickness (mm) was assessed using 3D-DXA software. Mean-adjusted values showed lower aBMD (7.5%-12.2%, effect size: 0.51-1.01) in the PHPT group compared with the control group (all P  aBMD and cortical 3D parameters are impaired in patients with PHPT versus healthy controls. The vBMD of the trabecular compartment seems to be affected, although to a lesser extent.
PB Oxford University Press
YR 2019
FD 2019-09-27
LK http://hdl.handle.net/10668/14590
UL http://hdl.handle.net/10668/14590
LA en
NO Gracia-Marco L, García-Fontana B, Ubago-Guisado E, Vlachopoulos D, García-Martín A, Muñoz-Torres M. Analysis of Bone Impairment by 3D DXA Hip Measures in Patients With Primary Hyperparathyroidism: A Pilot Study. J Clin Endocrinol Metab. 2020 Jan 1;105(1):dgz060.
NO We thank all participants and Ludovic Humbert for his supportwith 3D-DXA software. This work was supported by Fondode Investigación Sanitaria (Instituto de Salud Carlos III) (GrantPI18/01235) with co-financing from FEDER. In addition, LG-Mis supported by a fellowship from “La Caixa” Foundation (ID100010434) and the fellowship code is LCF/BO/PR19/11700007
DS RISalud
RD Apr 9, 2025