RT Journal Article
T1 Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients.
A1 Callejón-Leblic, María A
A1 Martín-Jiménez, Daniel I
A1 Moreno-Luna, Ramón
A1 Palacios-Garcia, Jose M
A1 Alvarez-Cendrero, Marta
A1 Vizcarra-Melgar, Julissa A
A1 Fernandez-Velez, Carlos
A1 Reyes-Tejero, Isabel M
A1 Maza-Solano, Juan
A1 Gonzalez-Garcia, Jaime
A1 Tena-García, Beatriz
A1 Acosta-Mosquera, María E
A1 Del Cuvillo, Alfonso
A1 Sánchez-Gómez, Serafín
K1 COVID-19
K1 UPSIT
K1 anosmia
K1 olfactory disorders
K1 parosmia
K1 prediction model
K1 smell disorders
K1 smell test
AB Although smell and taste disorders are highly prevalent symptoms of COVID-19 infection, the predictive factors leading to long-lasting chemosensory dysfunction are still poorly understood. 102 out of 421 (24.2%) mildly symptomatic COVID-19 patients completed a second questionnaire about the evolution of their symptoms one year after the infection using visual analog scales (VAS). A subgroup of 69 patients also underwent psychophysical evaluation of olfactory function through UPSIT. The prevalence of chemosensory dysfunction decreased from 82.4% to 45.1% after 12 months, with 46.1% of patients reporting a complete recovery. Patients older than 40 years (OR = 0.20; 95% CI: [0.07, 0.56]) and with a duration of loss of smell longer than four weeks saw a lower odds ratio for recovery (OR = 0.27; 95% CI: [0.10, 0.76]). In addition, 28 patients (35.9%) reported suffering from parosmia, which was associated with moderate to severe taste dysfunction at the baseline (OR = 7.80; 95% CI: [1.70, 35.8]). Among the 69 subjects who underwent the UPSIT, 57 (82.6%) presented some degree of smell dysfunction, showing a moderate correlation with self-reported VAS (r = -0.36, p = 0.0027). A clinically relevant number of subjects reported persistent chemosensory dysfunction and parosmia one year after COVID-19 infection, with a moderate correlation with psychophysical olfactory tests.
SN 2075-1729
YR 2022
FD 2022-08-17
LK http://hdl.handle.net/10668/21404
UL http://hdl.handle.net/10668/21404
LA en
DS RISalud
RD Apr 11, 2025