RT Journal Article
T1 Fe3O4-Au Core-Shell Nanoparticles as a Multimodal Platform for In Vivo Imaging and Focused Photothermal Therapy
A1 Caro, Carlos
A1 Gámez, Francisco
A1 Quaresma, Pedro
A1 Páez-Muñoz, Jose María
A1 Domínguez, Alejandro
A1 Pearson, John R.
A1 Pernía Leal, Manuel
A1 Beltrán, Ana M.
A1 Fernandez-Afonso, Yilian
A1 De la Fuente, Jesús M.
A1 Franco, Ricardo
A1 Pereira, Eulália
A1 García-Martín, Maria Luisa
K1 Imaging-guided therapy
K1 Multimodal imaging
K1 Contrast agent
K1 MRI
K1 CT
K1 Photothermal therapy
K1 Zebrafish
K1 Temperature
K1 Tissues
K1 Nanoparticles
K1 Imagen multimodal
K1 Medios de contraste
K1 Imagen por resonancia magnética
K1 TomografíacComputarizada por rayos X
K1 Terapia fototérmica
K1 Pez cebra
K1 Temperatura
K1 Tejidos
K1 Nanopartículas
K1 Neoplasias
AB In this study, we report the synthesis of gold-coated iron oxide nanoparticles capped with polyvinylpyrrolidone (Fe@Au NPs). The as-synthesized nanoparticles (NPs) exhibited good stability in aqueous media and excellent features as contrast agents (CA) for both magnetic resonance imaging (MRI) and X-ray computed tomography (CT). Additionally, due to the presence of the local surface plasmon resonances of gold, the NPs showed exploitable "light-to-heat" conversion ability in the near-infrared (NIR) region, a key attribute for effective photothermal therapies (PTT). In vitro experiments revealed biocompatibility as well as excellent efficiency in killing glioblastoma cells via PTT. The in vivo nontoxicity of the NPs was demonstrated using zebrafish embryos as an intermediate step between cells and rodent models. To warrant that an effective therapeutic dose was achieved inside the tumor, both intratumoral and intravenous routes were screened in rodent models by MRI and CT. The pharmacokinetics and biodistribution confirmed the multimodal imaging CA capabilities of the Fe@AuNPs and revealed constraints of the intravenous route for tumor targeting, dictating intratumoral administration for therapeutic applications. Finally, Fe@Au NPs were successfully used for an in vivo proof of concept of imaging-guided focused PTT against glioblastoma multiforme in a mouse model.
PB MDPI
YR 2021
FD 2021-03-20
LK http://hdl.handle.net/10668/4488
UL http://hdl.handle.net/10668/4488
LA en
NO Caro C, Gámez F, Quaresma P, Páez-Muñoz JM, Domínguez A, Pearson JR, et al. Fe3O4-Au Core-Shell Nanoparticles as a Multimodal Platform for In Vivo Imaging and Focused Photothermal Therapy. Pharmaceutics. 2021 Mar 20;13(3):416
DS RISalud
RD Apr 7, 2025