RT Journal Article
T1 AVIATOR: An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm.
A1 de Heer, Frederiek
A1 Kluin, Jolanda
A1 Elkhoury, Gebrine
A1 Jondeau, Guillaume
A1 Enriquez-Sarano, Maurice
A1 Schäfers, Hans-Joachim
A1 Takkenberg, Johanna J M
A1 Lansac, Emmanuel
A1 Aortic Valve Repair Research Network Investigators, 
K1 aortic valve regurgitation
K1 ascending aortic aneurysm
K1 international registry
K1 long-term echocardiographic follow-up
K1 outcome analysis
K1 valve surgery
AB Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. The AV repair research network includes surgeons, cardiologists, and scientists and established an online database compliant with the guidelines for reporting valve-related events. Prospective inclusion started from January 2013. Adult patients (18 years or older) who were operated on between 1995 and 2017 with complete procedural specification of the type of repair/replacement were selected for descriptive analysis. Currently 58 centers from 17 countries include 4896 patients with 89% AV repair (n = 4379) versus 11% AV replacement (n = 517). AV repair was either isolated (28%), or associated with tubular/partial root replacement (22%) or valve-sparing root replacement (49%) with an in-hospital mortality of 0.5%, 1.7%, and 1.2%, respectively. AV replacement was either isolated (24%), associated with tubular/partial root replacement (17%) or root replacement (59%) with an in-hospital mortality of 1%, 2.6%, and 2.0%, respectively. The multicenter surgical AVIATOR registry, by applying uniform definitions, should provide a solid evidence base to evaluate the place of repair versus replacement on the basis of long-term patient outcomes. Obtaining data completeness and adequate representation of all surgery types remain challenging. Toward the near future AVIATOR-medical will start to study natural history, as will AVIATOR-kids, with a focus on pediatric disease.
YR 2018
FD 2018-10-26
LK https://hdl.handle.net/10668/26866
UL https://hdl.handle.net/10668/26866
LA en
DS RISalud
RD Apr 17, 2025