RT Journal Article
T1 Biological Age Acceleration Is Lower in Women With Ischemic Stroke Compared to Men.
A1 Gallego-Fabrega, Cristina
A1 Muiño, Elena
A1 Cullell, Natalia
A1 Carcel-Marquez, Jara
A1 Lazcano, Uxue
A1 Soriano-Tarraga, Carolina
A1 Lledos, Miquel
A1 Llucia-Carol, Laia
A1 Aguilera-Simon, Ana
A1 Marin, Rebeca
A1 Prats-Sanchez, Luis
A1 Camps-Renom, Pol
A1 Delgado-Mederos, Raquel
A1 Martin-Campos, Jesus M
A1 Delgado, Pilar
A1 Marti-Fabregas, Joan
A1 Montaner, Joan
A1 Krupinski, Jerzy
A1 Jimenez-Conde, J
A1 Roquer, Jaume
A1 Fernandez-Cadenas, Israel
K1 DNA methylation
K1 aging
K1 ischemic stroke
K1 men
K1 women
AB Stroke onset in women occurs later in life compared with men. The underlying mechanisms of these differences have not been established. Epigenetic clocks, based on DNA methylation (DNAm) profiles, are the most accurate biological age estimate. Epigenetic age acceleration (EAA) measures indicate whether an individual is biologically younger or older than expected. Our aim was to analyze whether sexual dichotomy at age of stroke onset is conditioned by EAA. We used 2 DNAm datasets from whole blood samples of case-control genetic studies of ischemic stroke (IS), a discovery cohort of 374 IS patients (N women=163, N men=211), from GRECOS (Genotyping Recurrence Risk of Stroke) and SEDMAN (Dabigatran Study in the Early Phase of Stroke, New Neuroimaging Markers and Biomarkers) studies and a replication cohort of 981 IS patients (N women=411, N men=570) from BASICMAR register. We compared chronological age, 2 DNAm-based biomarkers of aging and intrinsic and extrinsic epigenetic age acceleration EAA (IEAA and extrinsic EAA, respectively), in IS as well as in individual IS etiologic subtypes. Horvath and Hannum epigenetic clocks were used to assess the aging rate. A proteomic study using the SOMAScan multiplex assay was performed on 26 samples analyzing 1305 proteins. Women present lower Hannum-extrinsic EAA values, whereas men have higher Hannum-extrinsic EAA values (women=-0.64, men=1.24, P=1.34×10-2); the same tendency was observed in the second cohort (women=-0.57, men=0.79, P=0.02). These differences seemed to be specific to cardioembolic and undetermined stroke subtypes. Additionally, 42 blood protein levels were associated with Hannum-extrinsic EAA (P This study shows that sex-specific underlying biological mechanisms associated with stroke onset could be due to differences in biological age acceleration between men and women.
PB Lippincott Williams & Wilkins
YR 2022
FD 2022-02-25
LK http://hdl.handle.net/10668/20203
UL http://hdl.handle.net/10668/20203
LA en
NO Gallego-Fabrega C, Muiño E, Cullell N, Cárcel-Márquez J, Lazcano U, Soriano-Tárraga C, et al. Biological Age Acceleration Is Lower in Women With Ischemic Stroke Compared to Men. Stroke. 2022 Jul;53(7):2320-2330.
DS RISalud
RD Apr 7, 2025