RT Journal Article
T1 Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
A1 Papadimitriou, Nikos
A1 Dimou, Niki
A1 Tsilidis, Konstantinos K.
A1 Banbury, Barbara
A1 Martin, Richard M.
A1 Lewis, Sarah J.
A1 Kazmi, Nabila
A1 Robinson, Timothy M.
A1 Albanes, Demetrius
A1 Aleksandrova, Krasimira
A1 Berndt, Sonja I.
A1 Bishop, D. Timothy
A1 Brenner, Hermann
A1 Buchanan, Daniel D.
A1 Bueno-de-Mesquita, Bas
A1 Campbell, Peter T.
A1 Castellví-Bel, Sergi
A1 Chan, Andrew T.
A1 Chang-Claude, Jenny
A1 Ellingjord-Dale, Merete
A1 Figueiredo, Jane C.
A1 Gallinger, Steven J.
A1 Giles, Graham G.
A1 Giovannucci, Edward
A1 Gruber, Stephen B.
A1 Gsur, Andrea
A1 Hampe, Jochen
A1 Hampel, Heather
A1 Harlid, Sophia
A1 Harrison, Tabitha A.
A1 Hoffmeister, Michael
A1 Hopper, John L.
A1 Hsu, Li
A1 Huerta, José María
A1 Huyghe, Jeroen R.
A1 Jenkins, Mark A.
A1 Keku, Temitope O.
A1 Kühn, Tilman
A1 La Vecchia, Carlo
A1 Le Marchand, Loic
A1 Li, Christopher I.
A1 Li, Li
A1 Lindblom, Annika
A1 Lindor, Noralane M.
A1 Lynch, Brigid
A1 Markowitz, Sanford D.
A1 Masala, Giovanna
A1 May, Anne M.
A1 Milne, Roger
A1 Monninkhof, Evelyn
A1 Moreno, Lorena
A1 Moreno, Victor
A1 Newcomb, Polly A.
A1 Offit, Kenneth
A1 Perduca, Vittorio
A1 Pharoah, Paul D. P.
A1 Platz, Elizabeth A.
A1 Potter, John D.
A1 Rennert, Gad
A1 Riboli, Elio
A1 Sanchez-Perez, Maria-Jose
A1 Schmit, Stephanie L.
A1 Schoen, Robert E.
A1 Severi, Gianluca
A1 Sieri, Sabina
A1 Slattery, Martha L.
A1 Song, Mingyang
A1 Tangen, Catherine M.
A1 Thibodeau, Stephen N.
A1 Travis, Ruth C.
A1 Trichopoulou, Antonia
A1 Ulrich, Cornelia M.
A1 van Duijnhoven, Franzel J. B.
A1 Van Guelpen, Bethany
A1 Vodicka, Pavel
A1 White, Emily
A1 Wolk, Alicja
A1 Woods, Michael O.
A1 Wu, Anna H.
A1 Peters, Ulrike
A1 Gunter, Marc J.
A1 Murphy, Neil
K1 Exercise
K1 Breast neoplasms
K1 Colorectal neoplasms
K1 Risk factors
K1 Analyses
K1 Ejercicio físico
K1 Neoplasias de la mama
K1 Neoplasias colorrectales
K1 Factores de riesgo
AB Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.
PB Springer Nature
YR 2020
FD 2020-01-30
LK http://hdl.handle.net/10668/4067
UL http://hdl.handle.net/10668/4067
LA en
NO Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, et al. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. Nat Commun. 2020 Jan 30;11(1):597
DS RISalud
RD May 9, 2025