RT Journal Article T1 Current Status of the Diagnosis and Management of Osteoporosis. A1 Aibar-Almazan, Agustin A1 Voltes-Martinez, Ana A1 Castellote-Caballero, Yolanda A1 Afanador-Restrepo, Diego Fernando A1 Carcelen-Fraile, Maria Del Carmen A1 Lopez-Ruiz, Elena K1 lifestyle habits K1 osteoporosis K1 regenerative medicine AB Osteoporosis has been defined as the silent disease of the 21st century, becoming a public health risk due to its severity, chronicity and progression and affecting mainly postmenopausal women and older adults. Osteoporosis is characterized by an imbalance between bone resorption and bone production. It is diagnosed through different methods such as bone densitometry and dual X-rays. The treatment of this pathology focuses on different aspects. On the one hand, pharmacological treatments are characterized by the use of anti-resorptive drugs, as well as emerging regenerative medicine treatments such as cell therapies and the use of bioactive hydrogels. On the other hand, non-pharmacological treatments are associated with lifestyle habits that should be incorporated, such as physical activity, diet and the cessation of harmful habits such as a high consumption of alcohol or smoking. This review seeks to provide an overview of the theoretical basis in relation to bone biology, the existing methods for diagnosis and the treatments of osteoporosis, including the development of new strategies. PB MDPI YR 2022 FD 2022-08-19 LK http://hdl.handle.net/10668/21190 UL http://hdl.handle.net/10668/21190 LA en NO Aibar-Almazán A, Voltes-Martínez A, Castellote-Caballero Y, Afanador-Restrepo DF, Carcelén-Fraile MDC, López-Ruiz E. Current Status of the Diagnosis and Management of Osteoporosis. Int J Mol Sci. 2022 Aug 21;23(16):9465 NO This work was funded by 1381650 from the 2014–2020 Operational Programme FEDER in Andalusia and the Mutua Madrileña Foundation: FMM-AP17196-2019. DS RISalud RD Apr 9, 2025