TY  - JOUR
AU  - Adam, Catherine
AU  - Bray, Thomas L
AU  - Pérez-López, Ana M
AU  - Tan, Ee Hong
AU  - Rubio-Ruiz, Belén
AU  - Baillache, Daniel J
AU  - Houston, Douglas R
AU  - Salji, Mark J
AU  - Leung, Hing Y
AU  - Unciti-Broceta, Asier
PY  - 2022
DO  - 10.1021/acs.jmedchem.1c01733
UR  - http://hdl.handle.net/10668/22589
T2  - Journal of medicinal chemistry
AB  - 5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from colorectal and pancreatic cancer. Because of its suboptimal route of administration and...
LA  - en
KW  - Animals
KW  - Antimetabolites, Antineoplastic
KW  - Biotransformation
KW  - Fluorouracil
KW  - HCT116 Cells
KW  - Half-Life
KW  - Hepatocytes
KW  - Humans
KW  - Liver
KW  - Metabolic Networks and Pathways
KW  - Mice
KW  - Palladium
KW  - Prodrugs
KW  - Protein Binding
KW  - Rats
KW  - Xenograft Model Antitumor Assays
TI  - A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry In Vitro and In Vivo.
TY  - research article
VL  - 65
ER  -