RT Journal Article
T1 Adherence to Clinical Practice Guidelines and Colorectal Cancer Survival: A Retrospective High-Resolution Population-Based Study in Spain.
A1 Carrasco-Peña, Francisco
A1 Bayo-Lozano, Eloisa
A1 Rodriguez-Barranco, Miguel
A1 Petrova, Dafina
A1 Marcos-Gragera, Rafael
A1 Carmona-Garcia, Maria Carmen
A1 Borras, Josep Maria
A1 Sanchez-Perez, Maria-Jose
K1 adherence
K1 cancer survival
K1 clinical practice guidelines
K1 colorectal cancer
K1 high-resolution study
K1 population-based study
AB Colorectal cancer (CRC) is the third most common cancer worldwide. Population-based, high-resolution studies are essential for the continuous evaluation and updating of diagnosis and treatment standards. This study aimed to assess adherence to clinical practice guidelines and investigate its relationship with survival. We conducted a retrospective high-resolution population-based study of 1050 incident CRC cases from the cancer registries of Granada and Girona, with a 5-year follow-up. We recorded clinical, diagnostic, and treatment-related information and assessed adherence to nine quality indicators of the relevant CRC guidelines. Overall adherence (on at least 75% of the indicators) significantly reduced the excess risk of death (RER) = 0.35 [95% confidence interval (CI) 0.28-0.45]. Analysis of the separate indicators showed that patients for whom complementary imaging tests were requested had better survival, RER = 0.58 [95% CI 0.46-0.73], as did patients with stage III colon cancer who underwent adjuvant chemotherapy, RER = 0.33, [95% CI 0.16-0.70]. Adherence to clinical practice guidelines can reduce the excess risk of dying from CRC by 65% [95% CI 55-72%]. Ordering complementary imagining tests that improve staging and treatment choice for all CRC patients and adjuvant chemotherapy for stage III colon cancer patients could be especially important. In contrast, controlled delays in starting some treatments appear not to decrease survival.
PB MDPI AG
YR 2020
FD 2020-09-09
LK http://hdl.handle.net/10668/16262
UL http://hdl.handle.net/10668/16262
LA en
NO Carrasco-Peña F, Bayo-Lozano E, Rodríguez-Barranco M, Petrova D, Marcos-Gragera R, Carmona-Garcia MC, et al. Adherence to Clinical Practice Guidelines and Colorectal Cancer Survival: A Retrospective High-Resolution Population-Based Study in Spain. Int J Environ Res Public Health. 2020 Sep 14;17(18):6697.
NO This work was supported in part by ERANET within the framework of the call on “Translationalresearch on tertiary prevention in cancer patients” (TRANSCAN) with funding from the Spanish National Instituteof Health Carlos III (grant number AC14/00036). Maria José Sánchez was also supported by the AndalusianDepartment of Health, Research, Development, and Innovation office project grant PI-0152/2017. The workconducted was part of HIGHCARE (High-resolution project on prognosis and care of cancer patients). The fundingsources had no role in the study design, collection, analysis or interpretation of data, the writing of the report,or the decision to submit the article for publication.
DS RISalud
RD Apr 20, 2025