RT Journal Article
T1 Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial.
A1 Daimiel, Lidia
A1 Martinez-Gonzalez, Miguel A
A1 Corella, Dolores
A1 Salas-Salvado, Jordi
A1 Schröder, Helmut
A1 Vioque, Jesus
A1 Romaguera, Dora
A1 Martinez, J Alfredo
A1 Wärnberg, Julia
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Cano-Ibáñez, Naomi
A1 Alonso-Gomez, Angel
A1 Tur, Josep A
A1 Tinahones, Francisco J
A1 Serra-Majem, Lluis
A1 Mico-Perez, Rafael M
A1 Lapetra, Jose
A1 Galdon, Alba
A1 Pinto, Xavier
A1 Vidal, Josep
A1 Mico, Victor
A1 Colmenarejo, Gonzalo
A1 Gaforio, Jose J
A1 Matia, Pilar
A1 Ros, Emilio
A1 Buil-Cosiales, Pilar
A1 Vazquez-Ruiz, Zenaida
A1 Sorli, Jose V
A1 Graniel, Indira Paz
A1 Cuenca-Royo, Aida
A1 Gisbert-Selles, Cristina
A1 Galmes-Panades, Aina M
A1 Zulet, M Angeles
A1 Garcia-Rios, Antonio
A1 Diaz-Lopez, Andres
A1 de la Torre, Rafael
A1 Galilea-Zabalza, Iñigo
A1 Ordovas, Jose M
AB Physical activity (PA) has been hypothesized to be effective to maintaining cognitive function and delay cognitive decline in the elderly, but physical fitness (PF) could be a better predictor of cognitive function. We aimed to study the association between PA and PF with cognitive function and quality of life using cross-sectional data from 6874 participants of the PREDIMED-Plus trial (64.9 ± 4.9 years, 48.5% female). PF and PA were measured with a Chair Stand Test, the REGICOR and Rapid Assessment Physical Activity questionnaires. Cognitive function was measured with Mini-mental State Examination, Control Oral Word Association Test, Trail Making Test and Digit Span tests; whereas health-related quality of life was assessed with the SF36-HRQL test. Cognitive and quality of life scores were compared among PF quartiles and PA levels (low, moderate and high) with ANCOVA and with Chair Stand repetitions and energy expenditure from total PA with multivariable linear regression adjusted for confounding factors. PF associated with higher scores in phonemic and semantic verbal fluency tests and with lower TMT A time. However, PA was not associated with the neurocognitive parameters evaluated. Both PF and PA levels were strongly associated with a better quality of life. We concluded that PF, but not PA, is associated with a better cognitive function. 
PB Nature Publishing Group
YR 2020
FD 2020-01-27
LK http://hdl.handle.net/10668/15168
UL http://hdl.handle.net/10668/15168
LA en
NO Daimiel L, Martínez-González MA, Corella D, Salas-Salvadó J, Schröder H, Vioque J, et al. Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial. Sci Rep. 2020 Feb 26;10(1):3472
NO The authors especially thank the PREDIMED-Plus participants for their enthusiastic collaboration, the PREDIMED-Plus personnel for their utstanding support, and the personnel of all associated primary care centers for their exceptional efort. Additional collaborators are listed in Annex I organized per recruitment center. Authors want to thank the invaluable contribution of Centros de Investigación Biomédica en Red: Obesidad y Nutrición CIBEROBN), Centros de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP) and Centros de Investigación Biomédica en Red: Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), which are initiatives of Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Food companies, Hojiblanca and Patrimonio Comunal Olivarero, donated extra-virgin olive oil and Almond Board of California, American Pistachio Growers and Paramount Farms donated nuts. We thank the PREDIMED-Plus BiobankNetwork as a part of the National Biobank Platform of the ISCIII for storing and managing the PREDIMEDPlus biological samples. Te PREDIMED-Plus trial was supported by the ofcial funding agency for biomedicalresearch of the Spanish government, ISCIII, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (fve coordinated FIS projects led by Jordi Salas-Salvadó and Josep Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/0147, PI14/00636, PI14/00972, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183,PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332), the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus granted to Jordi Salas-Salvadó, the European Research Council Advanced Research Grant 2013–2018 (340918) granted to Miguel Ángel Martínez-Gonzalez, the Recercaixa grant to Jordi Salas-Salvadó (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016, PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant and FEDER funds (CB06/03). Indira Paz Graniel is granted by the Spanish Ministry of Education, Culture and Sports (FPU 17/01925). None of the funding sources took part in the design, collection, analysis or interpretation of the data, or in the decision to submit the manuscript for publication.
DS RISalud
RD Apr 18, 2025