RT Journal Article
T1 CD46 Genetic Variability and HIV-1 Infection Susceptibility
A1 Serrano-Risquez, Carmen
A1 Omar, Mohamed
A1 Amparo Gomez-Vidal, Maria
A1 Miguel Real, Luis
A1 Antonio Pineda, Juan
A1 Rivero, Antonio
A1 Rivero-Juarez, Antonio
A1 Forthal, Donald
A1 Marquez, Francisco J.
A1 Lo Caputo, Sergio
A1 Clerici, Mario
A1 Biasin, Mara
A1 Caruz, Antonio
K1 HIV-1
K1 HIV exposed seronegative
K1 HESN
K1 CD46
K1 complement
K1 Recombinant glycoprotein-120 vaccine
K1 Complement regulatory proteins
K1 Natural-resistance
K1 Dendritic cells
K1 Nitric-oxide
K1 Receptor
K1 Expression
K1 Polymorphisms
K1 Individuals
K1 Association
AB CD46 is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. CD46 genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, CD46 function can be subverted by HIV-1 to evade attack by complement, a strategy shared by viruses of other families. We sought to determine the association between CD46 gene variants and HIV-1 acquired through intravenous drug use (IDU) and sexual routes (n = 823). Study subjects were of European ancestry and were HIV-1 infected (n = 438) or exposed but seronegative (n = 387). Genotyping of the rs2796265 SNP located in the CD46 gene region was done by allele-specific real-time PCR. A meta-analysis merging IDU and sexual cohorts indicates that the minor genotype (CC) was associated with increased resistance to HIV-1 infection OR = 0.2, 95% CI (0.07-0.61), p = 0.004. The HIV-1-protective genotype is correlated with reduced CD46 expression and alterations in the ratio of CD46 mRNA splicing isoforms.
PB Mdpi
YR 2021
FD 2021-11-01
LK https://hdl.handle.net/10668/25700
UL https://hdl.handle.net/10668/25700
LA en
DS RISalud
RD Apr 11, 2025