TY  - JOUR
AU  - Martínez-García, Pedro Manuel
AU  - García-Torres, Miguel
AU  - Divina, Federico
AU  - Terrón-Bautista, José
AU  - Delgado-Sainz, Irene
AU  - Gómez-Vela, Francisco
AU  - Cortés-Ledesma, Felipe
PY  - 2021
DO  - 10.1371/journal.pcbi.1007814
UR  - http://hdl.handle.net/10668/4184
T2  - PLOS Computational Biology
AB  - DNA topoisomerase II-β (TOP2B) is fundamental to remove topological problems linked to DNA metabolism and 3D chromatin architecture, but its cut-and-reseal catalytic mechanism can accidentally cause DNA double-strand breaks (DSBs) that can seriously...
LA  - en
PB  - Public Library of Science
KW  - Machine learning
KW  - Chromatin
KW  - Type II DNA topoisomerases
KW  - Thymocytes
KW  - Genome
KW  - MCF7 cells
KW  - Aprendizaje automático
KW  - Cromatina
KW  - ADN-Topoisomerasas de tipo II
KW  - Timocitos
KW  - Genoma
KW  - Células MCF-7
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome
KW  - Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::MCF-7 Cells
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Protein Binding
KW  - Medical Subject Headings::Anatomy::Cells::Thymocytes
KW  - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cell Nucleus::Cell Nucleus Structures::Intranuclear Space::Chromosomes::Chromosome Structures::Chromatin
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Isomerases::DNA Topoisomerases::DNA Topoisomerases, Type II
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Biological::Models, Genetic
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage::DNA Breaks::DNA Breaks, Double-Stranded
KW  - Medical Subject Headings::Phenomena and Processes::Mathematical Concepts::Probability
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Deoxyribonucleases::Endodeoxyribonucleases::Deoxyribonuclease I
TI  - Genome-wide prediction of topoisomerase IIβ binding by architectural factors and chromatin accessibility
TY  - research article
ER  -