RT Journal Article
T1 Effect of statin therapy in the outcome of bloodstream infections due to Staphylococcus aureus: a prospective cohort study.
A1 López-Cortés, Luis E
A1 Gálvez-Acebal, Juan
A1 Del Toro, María D
A1 Velasco, Carmen
A1 de Cueto, Marina
A1 Caballero, Francisco J
A1 Muniain, Miguel A
A1 Pascual, Alvaro
A1 Rodríguez-Baño, Jesús
K1 Antibacterianos
K1 Bacteriemia
K1 Inhibidores de Hidroximetilglutaril-CoA Reductasas
K1 Modelos de Riesgos Proporcionales
K1 Choque Séptico
K1 Infecciones Estafilocócicas
K1 Análisis de Supervivencia
AB INTRODUCTIONStatins have pleiotropic effects that could influence the prevention and outcome of some infectious diseases. There is no information about their specific effect on Staphylococcus aureus bacteremia (SAB).METHODSA prospective cohort study including all SAB diagnosed in patients aged ≥18 years admitted to a 950-bed tertiary hospital from March 2008 to January 2011 was performed. The main outcome variable was 14-day mortality, and the secondary outcome variables were 30-day mortality, persistent bacteremia (PB) and presence of severe sepsis or septic shock at diagnosis of SAB. The effect of statin therapy at the onset of SAB was studied by multivariate logistic regression and Cox regression analysis, including a propensity score for statin therapy.RESULTSWe included 160 episodes. Thirty-three patients (21.3%) were receiving statins at the onset of SAB. 14-day mortality was 21.3%. After adjustment for age, Charlson index, Pitt score, adequate management, and high risk source, statin therapy had a protective effect on 14-day mortality (adjusted OR = 0.08; 95% CI: 0.01-0.66; p = 0.02), and PB (OR = 0.89; 95% CI: 0.27-1.00; p = 0.05) although the effect was not significant on 30-day mortality (OR = 0.35; 95% CI: 0.10-1.23; p = 0.10) or presentation with severe sepsis or septic shock (adjusted OR = 0.89; CI 95%: 0.27-2.94; p = 0.8). An effect on 30-day mortality could neither be demonstrated on Cox analysis (adjusted HR = 0.5; 95% CI: 0.19-1.29; p = 0.15).CONCLUSIONSStatin treatment in patients with SAB was associated with lower early mortality and PB. Randomized studies are necessary to identify the role of statins in the treatment of patients with SAB.
PB Public Library of Science
YR 2013
FD 2013-12-23
LK http://hdl.handle.net/10668/2081
UL http://hdl.handle.net/10668/2081
LA en
NO López-Cortés LE, Gálvez-Acebal J, Del Toro MD, Velasco C, de Cueto M, Caballero FJ, et al. Effect of statin therapy in the outcome of bloodstream infections due to Staphylococcus aureus: a prospective cohort study. PLoS ONE. 2013; 8(12):e82958
NO Journal Article;
DS RISalud
RD Apr 17, 2025