RT Journal Article
T1 Epidemiological and clinical data of hospitalizations associated with respiratory syncytial virus infection in children under 5 years of age in Spain: FIVE multicenter study.
A1 Moreno-Perez, David
A1 Calvo, Cristina
K1 Children
K1 Hospitalization
K1 Respiratory syncytial virus
K1 Special populations
K1 Preescolar
K1 Estudios prospectivos
K1 Infecciones por virus sincitial respiratorio
K1 Virus sincitial respiratorio humano
K1 Factores de Riesgo
K1 España
AB BACKGROUNDRespiratory syncytial virus (RSV) is an important pathogen in lower respiratory tract infections (LRTI) in infants, but there are limited data concerning patients with underlying conditions and children older than 2 years of age.METHODSWe have designed a prospective observational multicenter national study performed in 26 Spanish hospitals (December 2011-March 2012). Investigational cases were defined as children with underlying chronic diseases and were compared with a group of previously healthy children (proportion 1:2). Clinical data were compared between the groups.RESULTSA total of 1763 children hospitalized due to RSV infection during the inclusion period were analyzed. Of them, 225 cases and 460 healthy children were enrolled in the study. Underlying diseases observed were respiratory (64%), cardiovascular (25%), and neurologic (12%), as well as chromosomal abnormalities (7·5%), immunodeficiencies (6·7%), and inborn errors of metabolism (3·5%). Cases were statistically older than previously healthy children (average age: 16·3 versus 5·5 months). Cases experienced hypoxemia more frequently (P < 0·001), but patients with respiratory diseases required oxygen therapy more often (OR: 2·99; 95% CI: 1·03-8·65). Mechanical ventilation was used more in patients with cardiac diseases (OR: 3·0; 95% CI: 1·07-8·44) and in those with inborn errors of metabolism (OR: 12·27; 95% CI: 2·11-71·47). This subgroup showed a higher risk of admission to the PICU (OR: 6·7, 95% CI: 1·18-38·04). Diagnosis of pneumonia was more frequently found in cases (18·2% versus 9·3%; P < 0·01).CONCLUSIONSA significant percentage of children with RSV infection have underlying diseases and the illness severity is higher than in healthy children.
PB Wiley Open Access
SN 1750-2640
YR 2014
FD 2014-03
LK http://hdl.handle.net/10668/1835
UL http://hdl.handle.net/10668/1835
LA en
NO Moreno-Perez D, Calvo C, Alfayate Miguélez S, Alvarez Alvarez C, Álvez González F, Arcos Machancoses JV, et al. Epidemiological and clinical data of hospitalizations associated with respiratory syncytial virus infection in children under 5 years of age in Spain: FIVE multicenter study. Influenza Other Respir Viruses. 2014                         ; 8(2):209-16
NO Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 5, 2025