RT Journal Article
T1 Physical activity phenotypes and mortality in older adults: a novel distributional data analysis of accelerometry in the NHANES.
A1 Matabuena, Marcos
A1 Felix, Paulo
A1 Hammouri, Ziad Akram Ali
A1 Mota, Jorge
A1 Del Pozo Cruz, Borja
K1 Accelerometry
K1 Distributional representation
K1 Longevity
K1 Physical activity
K1 Precision medicine
AB Physical activity is deemed critical to successful ageing. Despite evidence and progress, there is still a need to determine more precisely the direction, magnitude, intensity, and volume of physical activity that should be performed on a daily basis to effectively promote the health of individuals. This study aimed to assess the clinical validity of new physical activity phenotypes derived from a novel distributional functional analysis of accelerometer data in older adults. A random sample of participants aged between 65 and 80 years with valid accelerometer data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 was used. Five major clinical phenotypes were identified, which provided a greater sensitivity for predicting 5-year mortality and survival outcomes than age alone, and our results confirm the importance of moderate-to-vigorous physical activity. The new clinical physical activity phenotypes are a promising tool for improving patient prognosis and for directing to more targeted intervention planning, according to the principles of precision medicine. The use of distributional representations shows clear advantages over more traditional metrics to explore the effects of the full spectrum of the physical activity continuum on human health.
PB Springer
YR 2022
FD 2022-09-15
LK http://hdl.handle.net/10668/21797
UL http://hdl.handle.net/10668/21797
LA en
NO Matabuena M, Félix P, Hammouri ZAA, Mota J, Del Pozo Cruz B. Physical activity phenotypes and mortality in older adults: a novel distributional data analysis of accelerometry in the NHANES. Aging Clin Exp Res. 2022 Dec;34(12):3107-311
DS RISalud
RD Apr 10, 2025