RT Journal Article
T1 Mutation in ROBO3 Gene in Patients with Horizontal Gaze Palsy with Progressive Scoliosis Syndrome: A Systematic Review.
A1 Pinero-Pinto, Elena
A1 Pérez-Cabezas, Verónica
A1 Tous-Rivera, Cristina
A1 Sánchez-González, José-María
A1 Ruiz-Molinero, Carmen
A1 Jiménez-Rejano, José-Jesús
A1 Benítez-Lugo, María-Luisa
A1 Sánchez-González, María Carmen
K1 children
K1 familial horizontal
K1 gaze palsy
K1 mutation
K1 scoliosis
AB Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare, inherited disorder characterized by a congenital absence of conjugate horizontal eye movements with progressive scoliosis developing in childhood and adolescence. Mutations in the Roundabout (ROBO3) gene located on chromosome 11q23-25 are responsible for the development of horizontal gaze palsy and progressive scoliosis. However, some studies redefined the locus responsible for this pathology to a 9-cM region. This study carried out a systematic review in which 25 documents were analyzed, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. The search was made in the following electronic databases from January 1995 to October 2019: PubMed, Scopus, Web of Science, PEDRO, SPORT Discus, and CINAHL. HGPPS requires a multidisciplinary diagnostic approach, in which magnetic resonance imaging might be the first technique to suggest the diagnosis, which should be verified by an analysis of the ROBO3 gene. This is important to allow for adequate ocular follow up, apply supportive therapies to prevent the rapid progression of scoliosis, and lead to appropriate genetic counseling.
YR 2020
FD 2020-06-22
LK http://hdl.handle.net/10668/15818
UL http://hdl.handle.net/10668/15818
LA en
DS RISalud
RD Apr 11, 2025