RT Journal Article
T1 Consensus on the Definition of Advanced Parkinson's Disease: A Neurologists-Based Delphi Study (CEPA Study)
A1 Luquin, Maria-Rosario
A1 Kulisevsky, Jaime
A1 Martinez-Martin, Pablo
A1 Mir, Pablo
A1 Tolosa, Eduardo S.
K1 Cognitive impairment
K1 Nonmotor symptoms
K1 Progression
K1 Prevalence
K1 Dementia
AB To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concerning the relevance of several clinical features for APD diagnosis. In the firstround, 240 neurologists of the Spanish Movement Disorders Group participated in the study. The results obtainedwere incorporated into the questionnaire and both, results and questionnaire, were sent out to and fulfilled by 26 experts in Movement Disorders. Review of results fromthe second-round led to a classification of symptoms as indicative of "definitive," "probable," and "possible" APD. This classification was confirmed by 149 previous participating neurologists in a third-round, where 92% completely or very much agreed with the classification. Definitive symptoms of APD included disability requiring help for the activities of daily living, presence of motor fluctuations with limitations to perform basic activities of daily living without help, severe dysphagia, recurrent falls, and dementia. These results will help neurologists to identify some key factors in APD diagnosis, thus allowing users to categorize the patients for a homogeneous recognition of this condition.
PB John Wiley & Sons Ltd.	
SN 2090-8083
YR 2017
FD 2017-01-23
LK http://hdl.handle.net/10668/19056
UL http://hdl.handle.net/10668/19056
LA en
NO Luquin MR, Kulisevsky J, Martinez-Martin P, Mir P, Tolosa ES. Consensus on the Definition of Advanced Parkinson's Disease: A Neurologists-Based Delphi Study (CEPA Study). Parkinsons Dis. 2017;2017:1-8.
DS RISalud
RD Apr 11, 2025