RT Journal Article
T1 Comparative study of the efficacy and safety of bromfenac, nepafenac and diclofenac sodium for the prevention of cystoid macular edema after phacoemulsification.
A1 Chinchurreta Capote, Ana María
A1 Lorenzo Soto, Mercedes
A1 Rivas Ruiz, Francisco
A1 Caso Peláez, Enrique
A1 García Vazquez, Alicia
A1 Group OftaCosta, 
A1 Ramos Suárez, Antonio
K1 bromfenac
K1 cystoid macular edema
K1 diclofenac
K1 nepafenac
K1 phacoemulsification
AB To compare the efficacy, tolerability and safety of bromfenac 0.09%, nepafenac 0.1% or diclofenac 0.1% for the prophylaxis of the cystoid macular edema (CME) after phacoemulsification. Group sequential observational comparative study. After phacoemulsification, patients received two months for topical treatment of either diclofenac sodium, bromfenac or nepafenac. All patients received concomitant topical tobramycin 0.3% and topical prednisolone 1%. We measured CME using optical coherence tomography (OCT) central foveal thickness, macular thickness and total macular volume. We enrolled 243 patients from January to June 2015, and 35% received diclofenac, 32.9% bromfenac and 32.1% nepafenac. When we compared pre-operative to three weeks to two months, bromfenac was more effective in reducing foveal volume (21.3 and 35.4 mm3, respectively), compared with the diclofenac (1.3 and 11.5 mm3, respectively), and the nepafenac group, became more edematous 6.4 and 5.3, respectively. Totally 133 patients completed the post-surgical satisfaction questionnaire. Patients complained of eye stickiness in 13.8% whom we gave nepafenac, versus 10.3% whom we gave diclofenac sodium, and in 0 whom we gave bromfenac. Bromfenac is the best tolerated and is more effective than diclofenac and nepafenac in reducing CME after phacoemulsification.
SN 2222-3959
YR 2018
FD 2018-07-18
LK https://hdl.handle.net/10668/26768
UL https://hdl.handle.net/10668/26768
LA en
DS RISalud
RD Apr 12, 2025