RT Journal Article
T1 Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies.
A1 Alwan, Heba
A1 Villoz, Fanny
A1 Feller, Martin
A1 Dullaart, Robin P F
A1 Bakker, Stephan J L
A1 Peeters, Robin P
A1 Kavousi, Maryam
A1 Bauer, Douglas C
A1 Cappola, Anne R
A1 Yeap, Bu B
A1 Walsh, John P
A1 Brown, Suzanne J
A1 Ceresini, Graziano
A1 Ferrucci, Luigi
A1 Gussekloo, Jacobijn
A1 Trompet, Stella
A1 Iacoviello, Massimo
A1 Moon, Jae Hoon
A1 Razvi, Salman
A1 Bensenor, Isabela M
A1 Azizi, Fereidoun
A1 Amouzegar, Atieh
A1 Valdés, Sergio
A1 Colomo, Natalia
A1 Wareham, Nick J
A1 Jukema, J Wouter
A1 Westendorp, Rudi G J
A1 Kim, Ki Woong
A1 Rodondi, Nicolas
A1 Del Giovane, Cinzia
K1 diabetes
K1 Incidence
K1 Subclinical thyroid dysfunction
K1 Thyroid hormones
AB Few prospective studies have assessed whether individuals with subclinical thyroid dysfunction are more likely to develop diabetes, with conflicting results. In this study, we conducted a systematic review of the literature and an individual participant data analysis of multiple prospective cohorts to investigate the association between subclinical thyroid dysfunction and incident diabetes. We performed a systematic review of the literature in Medline, Embase, and the Cochrane Library from inception to February 11, 2022. A two-stage individual participant data analysis was conducted to compare participants with subclinical hypothyroidism and subclinical hyperthyroidism vs euthyroidism at baseline and the adjusted risk of developing diabetes at follow-up. Among 61 178 adults from 18 studies, 49% were females, mean age was 58 years, and mean follow-up time was 8.2 years. At the last available follow-up, there was no association between subclinical hypothyroidism and incidence of diabetes (odds ratio (OR) = 1.02, 95% CI: 0.88-1.17, I2 = 0%) or subclinical hyperthyroidism and incidence of diabetes (OR = 1.03, 95% CI: 0.82-1.30, I2 = 0%), in age- and sex-adjusted analyses. Time-to-event analysis showed similar results (hazard ratio for subclinical hypothyroidism: 0.98, 95% CI: 0.87-1.11; hazard ratio for subclinical hyperthyroidism: 1.07, 95% CI: 0.88-1.29). The results were robust in all sub-group and sensitivity analyses. This is the largest systematic review and individual participant data analysis to date investigating the prospective association between subclinical thyroid dysfunction and diabetes. We did not find an association between subclinical thyroid dysfunction and incident diabetes. Our results do not support screening patients with subclinical thyroid dysfunction for diabetes. Evidence is conflicting regarding whether an association exists between subclinical thyroid dysfunction and incident diabetes. We therefore aimed to investigate whether individuals with subclinical thyroid dysfunction are more prone to develop diabetes in the long run as compared to euthyroid individuals. We included data from 18 international cohort studies with 61 178 adults and a mean follow-up time of 8.2 years. We did not find an association between subclinical hypothyroidism or subclinical hyperthyroidism at baseline and incident diabetes at follow-up. Our results have clinical implications as they neither support screening patients with subclinical thyroid dysfunction for diabetes nor treating them in the hope of preventing diabetes in the future.
PB Oxford University Press
YR 2022
FD 2022-09-30
LK http://hdl.handle.net/10668/20445
UL http://hdl.handle.net/10668/20445
LA en
NO Alwan H, Villoz F, Feller M, Dullaart RPF, Bakker SJL, Peeters RP, et al. Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies. Eur J Endocrinol. 2022 Sep 30;187(5):S35-S46
DS RISalud
RD Apr 5, 2025