RT Journal Article
T1 Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study.
A1 Engels-Calvo, Virginia
A1 Cruz-Melguizo, Sara
A1 Abascal-Saiz, Alejandra
A1 Forcen-Acebal, Laura
A1 Sanchez-Migallon, Amalia
A1 Pintado-Recarte, Pilar
A1 Cuenca-Marin, Celia
A1 Marcos-Puig, Beatriz
A1 Del-Barrio-Fernandez, Pablo G
A1 Nieto-Velasco, Olga
A1 de-la-Cruz-Conty, Maria Luisa
A1 Martinez-Perez, Oscar
K1 COVID-19
K1 Assisted reproduction
K1 Cohort study
K1 Intensive care unit
K1 Pregnancy
AB To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes). Multicenter, prospective, observational study. 78 centers participating in the Spanish COVID19 Registry. 1,347 pregnant women with SARS-CoV-2 positive results registered consecutively between February 26 and November 5, 2020. The patients' information was collected from their medical records, and multivariable regression analyses were performed, controlling for maternal age and the clinical presentation of the infection. Obstetrics and neonatal outcomes, pregnancy comorbidities, intensive care unit admission, mechanical ventilation need, and medical conditions. The IVF group included 74 (5.5%) women whereas the spontaneous pregnancy group included 1,275 (94.5%) women. The operative delivery rate was high in all patients, especially in the IVF group, where cesarean section became the most frequent method of delivery (55.4%, compared with 26.1% of the spontaneous pregnancy group). The reason for cesarean section was induction failure in 56.1% of the IVF patients. IVF women had more gestational hypertensive disorders (16.2% vs. 4.5% among spontaneous pregnancy women, adjusted odds ratio [aOR] 5.31, 95% confidence interval [CI] 2.45-10.93) irrespective of oocyte origin. The higher rate of intensive care unit admittance observed in the IVF group (8.1% vs. 2.4% in the spontaneous pregnancy group) was attributed to preeclampsia (aOR 11.82, 95% CI 5.25-25.87), not to the type of conception. A high rate of operative delivery was observed in pregnant women infected with SARS-CoV-2, especially in those with IVF pregnancies; method of conception did not affect fetal or maternal outcomes, except for preeclampsia. 
PB Elsevier
YR 2021
FD 2021-04-12
LK http://hdl.handle.net/10668/17776
UL http://hdl.handle.net/10668/17776
LA en
NO Engels Calvo V, Cruz Melguizo S, Abascal-Saiz A, Forcén Acebal L, Sánchez-Migallón A, Pintado Recarte P, et al. Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study. Fertil Steril. 2021 Sep;116(3):731-740
DS RISalud
RD Apr 8, 2025