%0 Journal Article
%A Hassoun-Kheir, Nasreen
%A van-Werkhoven, C Henri
%A Dunning, Jake
%A Jaenisch, Thomas
%A van-Beek, Janko
%A Bielicki, Julia
%A Butler, Christopher C
%A Francois, Bruno
%A Harbarth, Stephan
%A Hernandez Padilla, Ana C
%A Horby, Peter
%A Koopmans, Marion
%A Lee, James
%A Rodriguez-Baño, Jesus
%A Tacconelli, Evelina
%A Themistocleous, Yrene
%A van-der-Velden, Alike W
%A Bonten, Marc
%A Goossens, Herman
%A de-Kraker, Marlieke E A
%T Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases.
%D 2022
%U http://hdl.handle.net/10668/22135
%X Emerging infectious diseases are a growing threat, through population growth , increased trade and travel , urbanization , deforestation , and climate change [1]. Clinical research in response to emerging infectious diseases is challenging; selecting and contracting the appropriate study sites for a trial is time consuming, and often too few patients can be timely recruited to acquire high-quality evidence about the best treatment strategies [2]. In 2014, the EU-funded PREPARE project (Platform foR European Preparedness Against (Re-)emerging Epidemics ) was initiated to rapidly respond to severe infectious diseases outbreaks . It initiated two adaptive platform trials, the REMAP-CAP [3] and the ALIC4E trial [4], determining the effectiveness of multiple treatment strategies for a single disease . The REMAP-CAP trial was designed for a pandemic of severe community-acquired pneumonia and expanded globally during the COVID-19 pandemic. It has already delivered 10 important conclusions for better treatment of COVID-19 [3].
%K Antimicrobial resistance
%K Emerging infectious diseases
%K Perpetual observational studies
%K Research network
%K Study methodology
%~