RT Journal Article
T1 Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells.
A1 Muñoz-Cano, Rosa
A1 San Bartolome, Clara
A1 Casas-Saucedo, Rocio
A1 Araujo, Giovanna
A1 Gelis, Sonia
A1 Ruano-Zaragoza, Maria
A1 Roca-Ferrer, Jordi
A1 Palomares, Francis
A1 Martin, Margarita
A1 Bartra, Joan
A1 Pascal, Mariona
K1 NSAID
K1 adenosin
K1 basophil
K1 cofactor
K1 exercise
K1 food allergy
K1 mast cell
K1 prostaglandin
AB Cofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58% of food anaphylaxis (FAn). Exercise, NSAIDs, and alcohol are the most frequently described, although the underlying mechanisms are poorly known. Several hypotheses have suggested the influence of these cofactors on basophils and mast cells (MCs). Exercise has been suggested to enhance MC activation by increasing plasma osmolarity, redistributing blood flow, and activating adenosine and eicosanoid metabolism. NSAIDs' cofactor effect has been related with cyclooxygenase inhibition and therefore, prostaglandin E2 (PGE2) production. Indeed, overexpression of adenosine receptor 3 (A3) gene has been described in NSAID-dependent FAn; A3 activation potentiates FcϵRI-induced MC degranulation. Finally, alcohol has been related with an increase of histamine levels by inhibition of diamino oxidase (DAO) and also with and increase of extracellular adenosine by inhibition of its uptake. However, most of these mechanisms have limited evidence, and further studies are urgently needed. In conclusion, the study of the immune-related mechanisms involved in food allergic reactions enhanced by cofactors is of the utmost interest. This knowledge will help to design both tailored treatments and prophylactic strategies that, nowadays, are non-existent.
PB Frontiers
YR 2020
FD 2020-12-31
LK http://hdl.handle.net/10668/17325
UL http://hdl.handle.net/10668/17325
LA en
NO Muñoz-Cano R, San Bartolome C, Casas-Saucedo R, Araujo G, Gelis S, Ruano-Zaragoza M, et al. Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells. Front Immunol. 2021 Feb 17;11:623071
DS RISalud
RD Apr 19, 2025