RT Journal Article
T1 Use of eltrombopag for secondary immune thrombocytopenia in clinical practice.
A1 González-López, Tomás J
A1 Alvarez-Román, María T
A1 Pascual, Cristina
A1 Sánchez-González, Blanca
A1 Fernández-Fuentes, Fernando
A1 Pérez-Rus, Gloria
A1 Hernández-Rivas, José A
A1 Bernat, Silvia
A1 Bastida, José M
A1 Martínez-Badas, María P
A1 Martínez-Robles, Violeta
A1 Soto, Inmaculada
A1 Olivera, Pavel
A1 Bolaños, Estefanía
A1 Alonso, Rafael
A1 Entrena, Laura
A1 Gómez-Nuñez, Marta
A1 Alonso, Arancha
A1 Yera Cobo, María
A1 Caparrós, Isabel
A1 Tenorio, María
A1 Arrieta-Cerdán, Esther
A1 Lopez-Ansoar, Elsa
A1 García-Frade, Javier
A1 González-Porras, José R
K1 efficacy
K1 eltrombopag
K1 immune thrombocytopenia
K1 safety
K1 thrombopoietin
AB Eltrombopag is a second-line treatment in primary immune thrombocytopenia (ITP). However, its role in secondary ITP is unknown. We evaluated the efficacy and safety of eltrombopag in secondary ITP in daily clinical practice. Eighty-seven secondary ITP patients (46 with ITP secondary to autoimmune syndromes, 23 with ITP secondary to a neoplastic disease subtype: lymphoproliferative disorders [LPDs] and 18 with ITP secondary to viral infections) who had been treated with eltrombopag were retrospectively evaluated. Forty-four patients (38%) had a platelet response, including 40 (35%) with complete responses. Median time to platelet response was 15 days (95% confidence interval, 7-28 days), and was longer in the LPD-ITP group. Platelet response rate was significantly lower in the LPD-ITP than in other groups. However, having achieved response, there were no significant differences between the durable response of the groups. Forty-three patients (49·4%) experienced adverse events (mainly grade 1-2), the commonest being hepatobiliary laboratory abnormalities. There were 10 deaths in this case series, all of which were related to pre-existing medical conditions. In routine clinical practice, eltrombopag is effective and well-tolerated in unselected patients with ITP secondary to both immune and infectious disorders. However, the response rate in LPD-ITP is low.
YR 2017
FD 2017-06-01
LK http://hdl.handle.net/10668/11261
UL http://hdl.handle.net/10668/11261
LA en
DS RISalud
RD Apr 10, 2025