%0 Journal Article
%A Rivero-Juarez, A
%A Gutierrez-Valencia, A
%A Castaño, M
%A Merino, D
%A Neukam, K
%A Ríos-Villegas, M J
%A Lopez-Ruz, M A
%A Jiménez-Aguilar, P
%A Marquez, M
%A Collado, A
%A Gomez-Vidal, A
%A Hernandez-Quero, J
%A Tellez, F
%A Fernandez-Fuertes, E
%A Rivero, A
%A López-Cortés, L F
%T Dimension of chronic hepatitis C virus in HIV-infected patients in the interferon-free era: an overview from south Spain.
%D 2015
%U http://hdl.handle.net/10668/2347
%X The implementation of hepatitis C (HCV) direct-acting antiviral drugs is prioritized in several populations in which its application provides the most immediate and impactful benefit. In this scenario, a precise knowledge of the situation of human immunodeficiency virus (HIV)/HCV chronic co-infection is required to adequately address this disease. This cross-sectional study was performed in 21 hospitals in Andalusia (Spain). The study population consisted of HIV-infected patients with an active HCV chronic infection who were not receiving HCV treatment at the time of inclusion. A total of 13,506 HIV-infected patients were included in the study. Of them, 2561 (18.9 %) presented chronic HCV infection. The majority of the patients included were on highly active antiretroviral therapy (HAART; 96.2 %), showed plasma levels with an undetectable HIV viral load (92.5 %), and had a good immunological status (median CD4+ cell count of 486 cells/mL). The HCV genotype distribution was as follows: 58.1 % were genotype 1, 1.1 % were genotype 2, 16.1 % were genotype 3, and 22.1 % were genotype 4 (2.6 % were missing data). In total, 24.8 % of the patients showed liver fibrosis stage F0-F1, 27.9 % showed stage F2, 16.7 % showed stage F3, and 21 % showed stage F4 (9.6 % were missing data). With regards to previous HCV treatment experiences, 68.05 % of the patients were naïve and 31.95 % had failed to respond to a previous treatment. The burden of HCV/HIV co-infected patients in our population was reported as one in five HIV-infected patients requiring HCV treatment. The implementation of extra resources to face this important health challenge is mandatory.
%K Hepacivirus
%K Hepatopatías
%K Hepatitis C
%K VIH
%K Fallo Hepático
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