RT Journal Article
T1 Thyroid hormones in diabetes, cancer, and aging
A1 Gauthier, Benoit R.
A1 Sola-García, Alejandro
A1 Cáliz-Molina, María Ángeles
A1 Lorenzo, Petra Isabel
A1 Cobo-Vuilleumier, Nadia
A1 Capilla-González, Vivian
A1 Martin-Montalvo, Alejandro
K1 Cancer
K1 Diabetes
K1 Health span
K1 Hyperthyroidism
K1 Hypothyroidism
K1 Life span
K1 Thyroid hormones
K1 Neoplasias
K1 Diabetes mellitus
K1 Hipertiroidismo
K1 Hipotiroidismo
K1 Longevidad
K1 Hormonas tiroideas
AB Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and human research have determined that thyroid hormones modulate cellular processes relevant for aging and for the majority of age-related diseases. While several studies have associated mild reductions on thyroid hormone function with exceptional longevity in animals and humans, alterations in thyroid hormones are serious medical conditions associated with unhealthy aging and premature death. Moreover, both hyperthyroidism and hypothyroidism have been associated with the development of certain types of diabetes and cancers, indicating a great complexity of the molecular mechanisms controlled by thyroid hormones. In this review, we describe the latest findings in thyroid hormone research in the field of aging, diabetes, and cancer, with a special focus on hepatocellular carcinomas. While aging studies indicate that the direct modulation of thyroid hormones is not a viable strategy to promote healthy aging or longevity and the development of thyromimetics is challenging due to inefficacy and potential toxicity, we argue that interventions based on the use of modulators of thyroid hormone function might provide therapeutic benefit in certain types of diabetes and cancers.
PB Anatomical Society and John Wiley & Sons Ltd
YR 2020
FD 2020
LK http://hdl.handle.net/10668/3606
UL http://hdl.handle.net/10668/3606
LA en
NO Gauthier BR, Sola-García A, Cáliz-Molina MÁ, Lorenzo PI, Cobo-Vuilleumier N, Capilla-González V, et al. Thyroid hormones in diabetes, cancer, and aging. Aging Cell. 2020 Nov;19(11):e13260
DS RISalud
RD Apr 17, 2025