RT Journal Article
T1 Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women.
A1 Garces, María Fernanda
A1 Rodriguez-Navarro, Haiver Antonio
A1 Buell-Acosta, Julieth Daniela
A1 Burgos-Cardenas, Alvaro Javier
A1 Franco-Vega, Roberto
A1 Maldonado-Acosta, Luis Miguel
A1 Eslava-Schmalbach, Javier
A1 Parada-Baños, Arturo José
A1 Castro-Pinzon, Andres
A1 Sanchez, Elizabeth
A1 Angel-Muller, Edith
A1 Lacunza, Ezequiel
A1 Castaño, Justo P
A1 Dieguez, Carlos
A1 Nogueiras, Rubén
A1 Ruiz-Parra, Ariel Ivan
A1 Caminos, Jorge Eduardo
K1 ANGPTL
K1 ANGPTL3
K1 insulin resistance
K1 preeclampsia
K1 pregnancy
AB Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. Serum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices. Levels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p 0.05). We describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta.
SN 1664-2392
YR 2021
FD 2021-04-13
LK https://hdl.handle.net/10668/28220
UL https://hdl.handle.net/10668/28220
LA en
DS RISalud
RD Apr 3, 2025