TY - JOUR AU - Grandal, Marta AU - Pernas, Berta AU - Tabernilla, Andres AU - MariƱo, Ana AU - Alvarez, Hortensia AU - Valcarce, Nieves AU - Mena, Alvaro AU - Castro-Iglesias, Angeles AU - Perez, Ana B AU - Delgado, Manuel AU - Poveda, Eva PY - 2018 DO - 10.1002/jmv.25048 UR - http://hdl.handle.net/10668/12111 T2 - Journal of medical virology AB - The presence of resistance-associated substitutions (RASs) at NS5A region might compromise the efficacy of Direct Acting Antiviral agents (DAAs). HCV resistance at NS5A region is mainly focused on patients with hepatitis C virus (HCV) genotypes 1a... LA - en PB - John Wiley & Sons, Inc. KW - HCV-infection KW - NS5A KW - RASs KW - genotype 1a KW - genotype 3 KW - Adult KW - Amino Acid Substitution KW - Antiviral Agents KW - Drug Resistance, Viral KW - Follow-Up Studies KW - Genotype KW - Hepacivirus KW - Hepatitis C, Chronic KW - Humans KW - Male KW - Middle Aged KW - Mutant Proteins KW - Mutation, Missense KW - Prevalence KW - Ribavirin KW - Sequence Analysis, DNA KW - Viral Nonstructural Proteins TI - Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies. TY - research article VL - 90 ER -