RT Journal Article
T1 Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality?
A1 Servia-Goixart, Lluis
A1 Lopez-Delgado, Juan C
A1 Grau-Carmona, Teodoro
A1 Trujillano-Cabello, Javier
A1 Bordeje-Laguna, M Luisa
A1 Mor-Marco, Esther
A1 Portugal-Rodriguez, Esther
A1 Lorencio-Cardenas, Carol
A1 Montejo-Gonzalez, Juan C
A1 Vera-Artazcoz, Paula
A1 Macaya-Redin, Laura
A1 Martinez-Carmona, Juan Francisco
A1 Iglesias-Rodriguez, Rayden
A1 Monge-Donaire, Diana
A1 Flordelis-Lasierra, Jose L
A1 Llorente-Ruiz, Beatriz
A1 Menor-Fernandez, Eva M
A1 Martinez de Lagran, Itziar
A1 Yebenes-Reyes, Juan C
K1 Enteral nutrition
K1 Intensive care unit
K1 Mortality
K1 Nutritional therapy
K1 Parenteral nutrition
AB The importance of artificial nutritional therapy is underrecognized, typically being considered an adjunctive rather than a primary therapy. We aimed to evaluate the influence of nutritional therapy on mortality in critically ill patients. This multicenter prospective observational study included adult patients needing artificial nutritional therapy for >48 h if they stayed in one of 38 participating intensive care units for ≥72 h between April and July 2018. Demographic data, comorbidities, diagnoses, nutritional status and therapy (type and details for ≤14 days), and outcomes were registered in a database. Confounders such as disease severity, patient type (e.g., medical, surgical or trauma), and type and duration of nutritional therapy were also included in a multivariate analysis, and hazard ratios (HRs) and 95% confidence intervals (95%CIs) were reported. We included 639 patients among whom 448 (70.1%) and 191 (29.9%) received enteral and parenteral nutrition, respectively. Mortality was 25.6%, with non-survivors having the following characteristics: older age; more comorbidities; higher Sequential Organ Failure Assessment (SOFA) scores (6.6 ± 3.3 vs 8.4 ± 3.7; P  Old age, higher organ failure scores, and greater nutritional risk appear to be associated with higher mortality. Patients who need parenteral nutrition after starting enteral nutrition may represent a high-risk subgroup for mortality due to illness severity and problems receiving appropriate nutritional therapy. Mean calorie and protein delivery also appeared to influence outcomes. 
PB Elsevier
YR 2021
FD 2021-11-08
LK http://hdl.handle.net/10668/22109
UL http://hdl.handle.net/10668/22109
LA en
NO Servia-Goixart L, Lopez-Delgado JC, Grau-Carmona T, Trujillano-Cabello J, Bordeje-Laguna ML, Mor-Marco E, et al. Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality? Clin Nutr ESPEN. 2022 Feb;47:325-332
NO The present research was granted by the Spanish Society of Nutrition and Metabolism (SENPE; Sociedad Espa~ nola de Metabolismo y Nutricion).
DS RISalud
RD Apr 19, 2025