%0 Journal Article
%A Servia-Goixart, Lluis
%A Lopez-Delgado, Juan C
%A Grau-Carmona, Teodoro
%A Trujillano-Cabello, Javier
%A Bordeje-Laguna, M Luisa
%A Mor-Marco, Esther
%A Portugal-Rodriguez, Esther
%A Lorencio-Cardenas, Carol
%A Montejo-Gonzalez, Juan C
%A Vera-Artazcoz, Paula
%A Macaya-Redin, Laura
%A Martinez-Carmona, Juan Francisco
%A Iglesias-Rodriguez, Rayden
%A Monge-Donaire, Diana
%A Flordelis-Lasierra, Jose L
%A Llorente-Ruiz, Beatriz
%A Menor-Fernandez, Eva M
%A Martinez de Lagran, Itziar
%A Yebenes-Reyes, Juan C
%T Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality?
%D 2021
%U http://hdl.handle.net/10668/22109
%X The importance of artificial nutritional therapy is underrecognized, typically being considered an adjunctive rather than a primary therapy. We aimed to evaluate the influence of nutritional therapy on mortality in critically ill patients. This multicenter prospective observational study included adult patients needing artificial nutritional therapy for >48 h if they stayed in one of 38 participating intensive care units for ≥72 h between April and July 2018. Demographic data, comorbidities, diagnoses, nutritional status and therapy (type and details for ≤14 days), and outcomes were registered in a database. Confounders such as disease severity, patient type (e.g., medical, surgical or trauma), and type and duration of nutritional therapy were also included in a multivariate analysis, and hazard ratios (HRs) and 95% confidence intervals (95%CIs) were reported. We included 639 patients among whom 448 (70.1%) and 191 (29.9%) received enteral and parenteral nutrition, respectively. Mortality was 25.6%, with non-survivors having the following characteristics: older age; more comorbidities; higher Sequential Organ Failure Assessment (SOFA) scores (6.6 ± 3.3 vs 8.4 ± 3.7; P  Old age, higher organ failure scores, and greater nutritional risk appear to be associated with higher mortality. Patients who need parenteral nutrition after starting enteral nutrition may represent a high-risk subgroup for mortality due to illness severity and problems receiving appropriate nutritional therapy. Mean calorie and protein delivery also appeared to influence outcomes. 
%K Enteral nutrition
%K Intensive care unit
%K Mortality
%K Nutritional therapy
%K Parenteral nutrition
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