RT Journal Article
T1 Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis.
A1 Zhou, Lisa
A1 Leonard, Alexandra
A1 Pavel, Ana B
A1 Malik, Kunal
A1 Raja, Aishwarya
A1 Glickman, Jacob
A1 Estrada, Yeriel D
A1 Peng, Xiangyu
A1 Del Duca, Ester
A1 Sanz-Cabanillas, Juan
A1 Ruano, Juan
A1 Xu, Hui
A1 Zhang, Ning
A1 Wen, Huei-Chi
A1 Gonzalez, Juana
A1 Garcet, Sandra
A1 Krueger, James G
A1 Guttman-Yassky, Emma
K1 Atopic dermatitis
K1 T(H)1
K1 T(H)17
K1 T(H)2
K1 T(H)22
K1 aging
K1 biomarker
K1 filaggrin
K1 hyperplasia
K1 loricrin
K1 skin
AB Atopic dermatitis (AD) shows differential clinical presentation in older compared with younger patients. Nevertheless, changes in the AD molecular profile with age are unknown. We sought to characterize age-related changes in the AD profile. We evaluated age-specific changes in lesional and nonlesional tissues and blood from patients with moderate-to-severe AD (n = 246) and age-matched control subjects (n = 71) using immunohistochemistry, quantitative real-time PCR, and Singulex in a cross-sectional study. Patients were analyzed by age group (18-40, 41-60, and ≥61 years). Although disease severity/SCORAD scores were similar across AD age groups (mean, approximately 60 years; P = .873), dendritic cell infiltrates (CD1b+ and FcεRI+, P  The adult AD profile varies with age. Although TH1/TH17 skewing increases in both patients with AD and control subjects, patients with AD show unique decreases in TH2/TH22 polarization and normalization of epithelial abnormalities. Thus age-specific treatment approaches might be beneficial for AD.
YR 2019
FD 2019-01-24
LK http://hdl.handle.net/10668/13466
UL http://hdl.handle.net/10668/13466
LA en
DS RISalud
RD Apr 7, 2025