%0 Journal Article
%A Zhou, Lisa
%A Leonard, Alexandra
%A Pavel, Ana B
%A Malik, Kunal
%A Raja, Aishwarya
%A Glickman, Jacob
%A Estrada, Yeriel D
%A Peng, Xiangyu
%A Del Duca, Ester
%A Sanz-Cabanillas, Juan
%A Ruano, Juan
%A Xu, Hui
%A Zhang, Ning
%A Wen, Huei-Chi
%A Gonzalez, Juana
%A Garcet, Sandra
%A Krueger, James G
%A Guttman-Yassky, Emma
%T Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis.
%D 2019
%U http://hdl.handle.net/10668/13466
%X Atopic dermatitis (AD) shows differential clinical presentation in older compared with younger patients. Nevertheless, changes in the AD molecular profile with age are unknown. We sought to characterize age-related changes in the AD profile. We evaluated age-specific changes in lesional and nonlesional tissues and blood from patients with moderate-to-severe AD (n = 246) and age-matched control subjects (n = 71) using immunohistochemistry, quantitative real-time PCR, and Singulex in a cross-sectional study. Patients were analyzed by age group (18-40, 41-60, and ≥61 years). Although disease severity/SCORAD scores were similar across AD age groups (mean, approximately 60 years; P = .873), dendritic cell infiltrates (CD1b+ and FcεRI+, P  The adult AD profile varies with age. Although TH1/TH17 skewing increases in both patients with AD and control subjects, patients with AD show unique decreases in TH2/TH22 polarization and normalization of epithelial abnormalities. Thus age-specific treatment approaches might be beneficial for AD.
%K Atopic dermatitis
%K T(H)1
%K T(H)17
%K T(H)2
%K T(H)22
%K aging
%K biomarker
%K filaggrin
%K hyperplasia
%K loricrin
%K skin
%~