RT Journal Article
T1 Increased blood levels of transforming growth factor β in patients with aortic dilatation.
A1 Rueda-Martinez, Carmen
A1 Lamas, Oscar
A1 Carrasco-Chinchilla, Fernando
A1 Robledo-Carmona, Juan
A1 Porras, Carlos
A1 Sanchez-Espin, Gemma
A1 Navarro, Manuel Jimenez
A1 Fernandez, Borja
K1 Aortic dilatation
K1 Bicuspid aortic valve
K1 Biomarker
K1 TGF-β
AB Recent studies have shown that patients with syndromic thoracic aortic aneurysm, particularly patients with bicuspid aortic valve, have increased blood levels of transforming growth factor β1 (TGF-β1), indicating this molecule as a prognostic biomarker. However, it is not known whether TGF-β1 is also elevated in the blood of patients with tricuspid aortic valve and aortic dilatation. We analysed the plasma levels of TGF-β1 in 52 patients with tricuspid or bicuspid aortic valve and with normal or dilated ascending aorta who underwent cardiac surgery in our hospital. TGF-β1 blood level was significantly increased two-fold in patients with tricuspid aortic valve and dilated aorta compared to patients with tricuspid aortic valve and normal aorta. Our results suggest that TGF-β1 blood levels may serve as a prognostic biomarker for patients with syndromic and non-syndromic thoracic aortic aneurysm. Further studies with larger cohorts of patients should be performed to confirm these results.
PB Oxford University Press
YR 2017
FD 2017-04-14
LK http://hdl.handle.net/10668/11363
UL http://hdl.handle.net/10668/11363
LA en
NO Rueda-Martínez C, Lamas O, Carrasco-Chinchilla F, Robledo-Carmona J, Porras C, Sánchez-Espín G, Navarro MJ, et al. Interact Cardiovasc Thorac Surg. 2017 Oct 1;25(4):571-574
DS RISalud
RD Apr 19, 2025